Aflatoxins — Experimental studies

  • P. G. Tulpule
International Symposium on Environmental Carcinogenesis Dec. 9–11, 1979, Cancer Research Institute (Tata Memorial Centre) Bombay Metabolic and Biochemical Studies


The susceptibility of animals to both chronic and acute aflatoxicosis is variable between species and depends upon not only the dose of the toxin and the duration of exposure but also upon the age, sex, and nutritional status of the animal. In general, acute toxicity is manifested by necrosis and cirrhosis, and chronic toxicity by carcinoma of the liver. Current research using both in vivo and in vitro studies has shown that the differences in response to aflatoxin in different animals can be attributed to their differential metabolism. The rates of metabolism and intermediate products formed are important factors in determining the type of toxic action of aflatoxin B1. According to these criteria, monkey and man are more susceptible to acute aflatoxicosis and relatively resistant to carcinogenic effects. On the other hand, animals, such as sheep and rat, are more susecptible to carcinogenic effects.

Key words

Aflatoxin B1 Metabolism Toxicity 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • P. G. Tulpule
    • 1
  1. 1.Food and Drug Toxicology Research CentreNational Institute of NutritionHyderabad 7India

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