Archiv für Mikrobiologie

, Volume 86, Issue 1, pp 57–68 | Cite as

Physiological and enzymatic aspects of histidine-mediated control of the tryptophan pathway

  • M. Elisabetta Guerzoni
Article
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Summary

It would thus appear that in Saccharomyces cerevisiae there are two forms of histidine-mediated control on the tryptophan pathway. In some strains histidine increases anthranilate synthetase and indole glycerol phosphate synthetase activities, while tryptophan synthetase decreases. In other strains histidine affects coordinately all enzymatic activities involved in tryptophan biosynthesis. The two groups of strains also differ in the formation, during the growth of the enzymatic activities involved in tryptophan biosynthesis. This difference in the relative rates at which the two enzymes are formed may explain the accumulation of intermediates in the cultural media of some strains. The derepression of anthranilate synthetase and indole glycerol phosphate synthetase activities by histidine is particularly manifest in the auxotrophic his3 strains that show these activities very depressed in histidine starvation; large amounts of this amino acid stimulate them to a considerably greater extent than in prototrophic strains.

Keywords

Enzyme Enzymatic Activity Glycerol Tryptophan Histidine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

IGP

imidazole glycerol phosphate

InGP

indole glycerol phosphate

ASase

anthranilate synthetase

InGPase

indole-3-glycerol phosphate synthetase

TSase

tryptophan synthetase

Tris

tris (hydroxymethyl)-aminomethane

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • M. Elisabetta Guerzoni
    • 1
  1. 1.Istituto di Microbiologia agraria dell'Università di BolognaItalia

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