Mammalian Genome

, Volume 5, Issue 10, pp 640–642

The cDNA sequence and chromosomal location of the human SOX2 gene

  • M. Stevanovic
  • O. Zuffardi
  • J. Collignon
  • R. Lovell-Badge
  • P. Goodfellow
Short Communications


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Chardard, D., Chesnel, A., Goze, C., Dournon, C., Berta, P. (1993). PwSOX-1: the first member of the Sox gene family in Urodeles. Nucleic Acids Res. 21, 3576.Google Scholar
  2. Collignon, J. (1993). Study of a new family of genes related to the mammalian testis determining gene. PhD Thesis, London University.Google Scholar
  3. Denny, P., Swift, S., Brand, N., Dabhade, N., Barton, P., Ashworth, A. (1992a). A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 20, 2887.Google Scholar
  4. Denny, P., Swift, S., Connor, F., Ashworth, A. (1992b) An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. EMBO J. 11, 3705–3712.Google Scholar
  5. Farr, C.J., Easty, D.J., Ragoussis, J., Collignon, J., Lovell-Badge, R., Goodfellow, P.N. (1993) Characterisation and mapping of the human SOX4 gene. Mamm. Genome 4, 577–584Google Scholar
  6. Goodfellow, P.N., Lovell-Badge, R. (1993). SRY and sex determination in mammals. Annu. Rev. Genet. 27, 71–92Google Scholar
  7. Goze, C., Poulat, F., Berta, P. (1993) Partial cloning of SOX11 and SOX12, two new human SOX genes. Nucleic Acids Res. 21, 2943.Google Scholar
  8. Griffiths, R. (1991). The isolation of conserved DNA sequences related to the human sex-determining region Y gene from the lesser blackbacked gull (Larus fuscus). Proc. R. Soc. Lond. [Biol.] 244, 123–128.Google Scholar
  9. Gubbay, J., Collignon, J., Koopman, P., Capel, B., Economou, A., Münsterberg, A., Vivian, N., Goodfellow, P., Lovell-Badge, R. (1990). A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346, 245–250.Google Scholar
  10. Harley, V.R., Jackson, D.I., Hextall, P.J., Hawkins, J.R., Berkovitz, G.D., Sockanathan, S., Lovell-Badge, R., Goodfellow, P.N. (1992). DNA binding activity of recombinant SRY derived from normal males and XY females. Science 255, 453–457.Google Scholar
  11. Kozak, M. (1987). An analysis of 5′ noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125–8148.Google Scholar
  12. Nasrin, N., Buggs, C., Kong, X.F., Carnazza, J., Goebl, M., Alexander-Bridges, M. (1991). DNA-binding properties of the product of the testis-determining gene and a related protein. Nature 354, 317–320.Google Scholar
  13. Ner, S.S. (1992). HMGs everywhere. Current Biol 2, 208–210Google Scholar
  14. Rossi, E., Zarrilla, R., Zuffardi, O. (1993). Regional assignment of the gene coding for the human Grave's disease autoantigen to 10q21.3-q22.1. Hum. Genet. 90, 653–654.Google Scholar
  15. Sanger, F., Nicklen, S., Coulson, A.R. (1977). DNA sequencing with chain-termination inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463–5467.Google Scholar
  16. Schilham, M.W., van-Eijk, M., van der Wetering, M., Clevers, H.C. (1993). The murine Sox-4 protein is encoded on a single exon. Nucleic Acids Res. 21, 2009.Google Scholar
  17. Schweizer, D. (1981). Counterstain-enhanced chromosome banding. Hum. Genet. 57, 1–14Google Scholar
  18. Sinclair, A.H., Berta, P., Palmer, M.S., Hawkins, J.R., Griffiths, B.L., Smith, M.J., Foster, J.W., Frischauf, A-M., Lovell-Badge, R., Goodfellow, P.N. (1990). A gene from the sex determining region encoding a protein with homology to a conserved DNA-binding motif. Nature 346, 240–244.Google Scholar
  19. Stevanovic, M., Lovell-Badge, R., Collignon, J., Goodfellow, P.N. (1993). SOX3 is an X-linked gene related to SRY. Hum. Mol. Genet. 2, 2013–2018.Google Scholar
  20. van de Wetering, M., Clevers, H. (1993). Sox-15, a novel member of the murine Sox family of HMG box transcription factors. Nucleic Acids Res. 21, 1669.Google Scholar
  21. Wright, E.M., Snopek, B., Koopman, P. (1993). Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res 21, 744.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1994

Authors and Affiliations

  • M. Stevanovic
    • 1
  • O. Zuffardi
    • 2
  • J. Collignon
    • 3
  • R. Lovell-Badge
    • 3
  • P. Goodfellow
    • 1
  1. 1.Department of GeneticsUniversity of CambridgeCambridgeUK
  2. 2.Biologia General E GeneticaPaviaItaly
  3. 3.Medical Research CouncilNational Institute for Medical ResearchLondonUK
  4. 4.Genetic EngineeringBelgradeYugoslavia
  5. 5.The Biological LaboratoriesHarvard UniversityCambridgeUSA

Personalised recommendations