An increase in intraocular pressure due to clonidine

  • H. C. Innemee
  • P. A. van Zwieten
Article
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Summary

The rise in intraocular pressure (IOP) observed after the administration of clonidine into the carotid arteries was studied in anesthetized rats and cats. This increase of IOP proved to be blocked by the α-sympathicolytic agent piperoxane and by the muscle relaxants d-tubocurarine and gallamine. Our experiments suggest that the elevation of IOP after clonidine injection is due to contraction of the eyelids and extraocular muscles. In these tissues α-adrenoceptors seem to play a part.

Keywords

Public Health Carotid Artery Clonidine Muscle Relaxant Intraocular Pressure 
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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • H. C. Innemee
    • 1
  • P. A. van Zwieten
    • 1
  1. 1.Department of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamThe Netherlands

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