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Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus)

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Summary

The effect of the tumor promoter TPA and its inactive structural analogue 4-O-methyl-TPA on the induction of dorsal skin melanosis in the normal Syrian golden hamster and on the promotion of melanomas in DMBA-initiated animals was investigated. Both phenomena were observed in TPA-treated hamsters but could not be detected after exposure of animals to 4-O-methyl-TPA. In contrast to results obtained with a variety of other laboratory animals, neither TPA nor 4-O-methyl-TPA were able to induce epidermal hyperplasia of hamster dorsal skin.

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Abbreviations

DMBA:

7,12-dimethylbenz(a)anthracene

TPA:

12-O-tetradecanoylphorbol-13-acetate

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Correspondence to K. Goerttler.

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Goerttler, K., Hecker, E., Loehrke, H. et al. Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus). J Cancer Res Clin Oncol 103, 305–311 (1982). https://doi.org/10.1007/BF00409706

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Key words

  • Two-stage skin carcinogenesis
  • DMBA
  • TPA
  • 4-O-Methyl-TPA
  • Melanosis
  • Melanomas