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Archives of Dermatological Research

, Volume 271, Issue 3, pp 259–264 | Cite as

Polymorphonuclear granulocyte chemotaxis and chemotactic factor generation by concanavalin A-stimulated peripheral blood mononuclear cells in patients with psoriasis

  • M. Csató
  • A. Dobozy
  • J. Hunyadi
  • Sz. A. Kenderessy
  • N. Simon
Original Contributions

Summary

Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosanactivated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin A produced an increased amount of lymphocyte derived chemotactic factor (LDCF) as compared to that in the case of healthy persons. The LDCF proved to be chemokinetic for the psoriatic granulocyte.

It is postulated that these two phenomena may play a role in the pathogenesis of psoriasis.

Key words

Granulcyte chemotaxis Chemotactic factor generation Psoriasis 

Zusammenfassung

Die polymorphkernigen Leukocyten von Patienten mit Psoriasis zeigten eine signifikant gesteigerte chemotaktische Reaktionsfähigkeit gegen Zymosan-aktiviertes menschliches Serum im Vergleich zu Granulocyten von gesunden Personen. Weiterhin produzierten mit Concanavalin A stimulierte psoriatische mononucleare Zellen verglichen mit denen gesunder Personen mehr lymphocytenstämmigen chemotaktischen Faktor (lymphocyte-derived chemotactic factor-LDCF). LDCF erwies sich als chemokinetisch für die psoriatischen Granulocyten. Es wird vermutet, daß diese Phänomena in der Pathogenese der Psoriasis eine Rolle spielen.

Schlüsselwörter

Granulocyten-chemotaxis Chemotaktischer Faktor Psoriasis 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • M. Csató
    • 1
  • A. Dobozy
    • 1
  • J. Hunyadi
    • 1
  • Sz. A. Kenderessy
    • 1
  • N. Simon
    • 1
  1. 1.Dept. of DermatologyUniversity Medical SchoolSzegedHungary

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