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The effects of dexamphetamine, sodium amobarbital and meprobamate on critical frequency of flicker under two different surround illuminations

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The effects on c.f.f. of three drugs, i.e. Sodium Amytal, Dexedrine and meprobamate, and of a placebo, were tested for two different surround luminances, one higher than, and the other about equal to the test field luminance. Separate analyses were applied to c.f.f.'s obtained in the descending and ascending series as well as on the mean of those two. They showed good agreement in general and revealed the following results:

Sodium Amytal lowered c.f.f. under both surround conditions, and Dexedrine raised it likewise under both surround conditions. Meprobamate produced effects similar to Sodium Amytal but not statistically significant. When c.f.f.'s were compared for the two surrounds, the brighter surround, under all treatments, produced lower c.f.f. than did the equal surround. Under Sodium Amytal, however, this trend appeared to be slightly more accentuated than under other drugs and the placebo, but it was not statistically significant.

The possible action of the drugs in changing the sensitivity of the central nervous system to flicker, as well as in altering the degree of the lateral interaction in the nervous system is discussed, and a plan for further research under modified conditions indicated.

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  1. Adler, H. F., W. L. Burkhardt, A. C. Ivy and A. J. Atkinson: Effect of various drugs on psychomotor performance at ground level and at simulated altitudes of 18,000 feet in a low pressure chamber. J. Aviat. Med. 21, 221–236 (1950).

  2. Aiba, S.: The effects of sodium amytal and dextro-amphetamine on the Bidwell phenomenon. (To be published.)

  3. Alpern, M.: Meta-contrast. J. opt. Soc. Amer. 43, 648–657 (1953).

  4. Baker, C. H., and E. A. Bott: Effects of timing of visual stimuli on binocular fusion and flicker. Canad. J. Psychol. 6, 9–17 (1951).

  5. Barlow, H. B., R. Fitzhugh and S. W. Kuffler: Change of organization in the receptive fields of the cat's retina during dark-adaptation. J. Physiol. (Lond.) 137, 338–354 (1957).

  6. Bartley, S. H.: Temporal and spatial summation of extrinsic impulses with the intrinsic activity of the cortex. J. cell. comp. Physiol. 8, 41–62 (1936).

  7. Berg, O.: Effect of Evipan on the flicker fusion intensity in brain injuries. Acta psychiat. (Kbh.) Suppl. 58, 1–116 (1949).

  8. Berger, C.: Area of retinal image and flicker fusion frequency. Acta physiol. scand. 28, 224–233 (1952).

  9. —: Illumination of surrounding field and flicker fusion frequency with foveal images of different sizes. Acta physiol. scand. 30, 161–170 (1954).

  10. —: Meprobamate: its pharmacological properties and clinical uses. Int. Rec. Med. 169, 184–196 (1956).

  11. Bidwell, S.: On subjective colour phenomena attending sudden changes of illumination. Proc. roy. Soc. Lond. 60, 368–377 (1896).

  12. —: On the negative after-images following brief retinal excitation. Proc. roy. Soc. 60, 268–271 (1896).

  13. Bogoslovski, A. I.: Changements de la fréquence critique des papillotements lumineux à caractère de réflexe conditionné. Arch. Ophtal. (Paris) 2, 219–227 (1938).

  14. Creed, R. S., and T. C. Ruch: Regional variations in sensitivity to flicker. J. Physiol. (Lond.) 74, 407–423 (1932).

  15. Crozier, W. J., and E. Wolf: Critical intensities for visual flicker, monocular and binocular. J. gen. Physiol. 24, 505–534 (1941).

  16. Danis, P.: Modifications de l'électrorétinogramme du rat produites par l'injection intra-artérielle proche de potassium, de vératrine et de narcotiques. J. Physiol. (Paris) 48, 479–483 (1956).

  17. Duncan, D. B.: Multiple range and multiple F tests. Biometrics 11, 1–42 (1955).

  18. Eysenck, H. J. (Ed.): Experiments in personality. London: Routledge & Kegan Paul (1960).

  19. —, and S. Aiba: The effects of stimulant and depressant drugs on the suppression of the primary visual stimulus. J. ment. Sci. 103, 661–665 (1957).

  20. Forbes, A., and B. R. Morrison: Cortical response to sensory stimulation under deep barbiturate narcosis. J. Neurophysiol. 2, 112–118 (1939).

  21. —, A. F. Battista, P. O. Chatfield and T. P. Jarcia: Refractory phase in cerebral mechanism. Electroenceph. clin. Neurophysiol. 1, 141–175 (1949).

  22. Fry, G. A., and S. H. Bartley: The effect of steady stimulation of one part of the retina upon the critical frequency in another. J. exp. Psychol. 19, 351–356 (1936).

  23. Gastaut, H.: Étude électrographique du cycle d'excitabilité cortical. Electroenceph. clin. Neurophysiol. 3, 401–428 (1951).

  24. —, J. Corriol et A. Roger: Le cycle d'excitabilité des systèmes afferent corticaux chez l'homme. Rev. neurol. 84, 602 (1951).

  25. Geldard, F. A.: Foveal sensitivity as influenced by peripheral stimulation. J. gen. Psychol. 7, 185–189 (1932).

  26. —: Flicker relation within the fovea. J. opt. Soc. Amer. 24, 299–302 (1934).

  27. Graham, C. H., and R. Granit: Comparative studies on the peripheral and central retina. VI. Inhibition, summation and synchronization of impulses in the retina. Amer. J. Physiol. 98, 664–673 (1931).

  28. Granit, R., and P. Harper: Comparative studies on the peripheral and central retina. II. Synaptic reactions in the eye. Amer. J. Physiol. 95, 211–218 (1930).

  29. —, and K. Tansley: Rods, cones and the localization of pre-excitatory inhibition in the mammalian retina. J. Physiol. (Lond.) 107, 54–66 (1948).

  30. Hendley, C. D., T. E. Lynes and F. M. Berger: Effect of 2-methyl-2-n-propyl-1, 3-propaneidiol dicarbamate (Miltown) on central nervous system. Proc. Soc. exp. Biol. (N. Y.) 87, 608 (1954).

  31. Jarcho, L. W.: Excitability of cortical afferent systems in relation to anesthesia. Fed. Proc. 6, 137 (1947).

  32. —: Excitability of cortical afferent system during barbiturate anesthesia. J. Neurophysiol. 12, 447–457 (1949).

  33. Knox, G. W.: Effect of auditory stimulation on the visual c.f.f. J. gen. Psychol. 33, 139–143 (1945).

  34. Kravkov, S. V.: Action of aural stimuli on flicker fusion. Fiziol. Ž. SSSR. 28, 313–322 (1940).

  35. Kuffler, S. W.: Discharge patterns and functional organization of mammalian retina. J. Neurophysiol. 16, 37–68 (1953).

  36. Landis, C., and J. Zubin: Effect of thonzylamine hydrochloride and phenobarbital sodium on certain psychological functions. J. Psychol. (Provincetown) 31, 181–200 (1951).

  37. Lythgoe, R. J., and K. Tansley: The relation of the critical frequency of flicker to the adaptation of the eye. Proc. roy. Soc. B 105, 60–92 (1929).

  38. Marshall, W.: Observation on subcortical somatic sensory mechanisms of cats under nembutal anesthesia. J. Neurophysiol. 4, 25–43 (1941).

  39. —, C. N. Woolsey and P. Bard: Observation on cortical somatic sensory mechanisms of cat and monkey. J. Neurophysiol. 4, 1–24 (1941).

  40. Morin, G., H. Gastaut et R. Naquet: Le cycle d'excitabilité des systèmes afferent corticaux chez l'homme. Rev. neurol. 84, 605 (1951).

  41. Nakao, H., and W. P. Koella: Influence of nociceptive stimuli on evoked subcortical and cortical potentials in cat. J. Neurophysiol. 19, 187–195 (1956).

  42. Roback, G. S., L. R. Krasno and A. C. Ivy: Drug effects of flicker fusion threshold. J. appl. Physiol. 4, 566–574 (1952).

  43. Rosenzweig, M. R., and W. A. Rosenblith: Responses to successive auditory stimuli at the cochlea and at the auditory cortex. Psychol. Monogr. 67, No 13, 26 pp. (1953).

  44. Schenck, F.: Über intermittierende Netzhautreizung. I. Pflügers Arch. ges. Physiol. 64, 165–178 (1896).

  45. Schmidtke, H.: Über die Messung der psychischen Ermüdung mit Hilfe des Flimmertests. Psychol. Forsch. 23, 409–463 (1951).

  46. Sherrington, C.: On binocular flicker and the correlation of activity of ‘corresponding’ retinal points. Brit. J. Psychol. 1, 26–60 (1904).

  47. Simonson, E., and N. Enzer: Effect of Pervitin (desoxyephedrine) on fatigue of the central nervous system. J. industr. Hyg. 24, 205–209 (1942).

  48. — —, and S. S. Blankstein: Effect of amphetamine (Benzedrine) on fatigue of the central nervous system. War Med. (Chicago) 1, 690–695 (1941).

  49. —, M. S. Fox and N. Enzer: Influence of vestibular stimulation on the fusion frequency of flicker. J. exp. Psychol. 29, 253–255 (1941).

  50. Stigler, R.: Chronophorische Studien über den Umgebungskontrast. Pflügers Arch. ges. Physiol. 134, 365–435 (1910).

  51. Trent, S. E.: Narcosis and visual contour clarity. J. gen. Psychol. 36, 65–78 (1947).

  52. Vernon, M. D.: Binocular perception of flicker. Brit. J. Psychol. 24, 351–374 (1924)

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Aiba, S. The effects of dexamphetamine, sodium amobarbital and meprobamate on critical frequency of flicker under two different surround illuminations. Psychopharmacologia 1, 89–101 (1959). https://doi.org/10.1007/BF00409108

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  • Sodium
  • Placebo
  • Nervous System
  • Central Nervous System
  • Modify Condition