Psychopharmacologia

, Volume 1, Issue 1, pp 29–38

Comparison of the reactions induced by psilocybin and LSD-25 in man

  • Harris Isbell
Article

Summary

  1. 1.

    The reaction induced by oral administration of 57 to 114 mcgm/kg of 0-Phosphoryl-4-hydroxy-N-dimethyltryptamine (psilocybin) has been compared with that induced by a placebo and LSD-25 (1.0 to 1.5 mcgm/kg) in 9 subjects.

     
  2. 2.

    Both LSD and psilocybin caused elevations in body temperature, pulse and respiratory rates, and systolic blood pressure. Threshold for elicitation of the kneejerk was decreased by both drugs.

     
  3. 3.

    After both drugs, abnormal mental states characterized by feelings of strangeness, difficulty in thinking, anxiety, altered sensory perception (particularly visual), elementary and true visual hallucinations, and alterations of body image were reported by the subjects.

     
  4. 4.

    The effects of psilocybin did not persist as long as those of LSD.

     
  5. 5.

    LSD is 100 to 150 times as potent as psilocybin.

     

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abramson, H. A., M. E. Jarvik, M. R. Kaufman, C. Kornetsky, A. Levine and M. Wagner: Lysergic acid diethylamide (LSD-25): I. Physiological and perceptual responses. J. Psychol. (Provincetown) 39, 3–60 (1955).Google Scholar
  2. Bliss, C. I.: The statistics of bioassay, with special reference to the vitamins. New York: Academic Press Inc. 1952.Google Scholar
  3. Cerletti, A.: Pharmacology of psilocybin. Paper, presented at First Internat. Meeting of Neuro-Psycho-Pharmacology, Rome (Italy) Sept. 8–13, 1958.Google Scholar
  4. Edwards, A. L.: Statistical analysis for students in psychology and education, 1. New York: Rhinehart & Co. 1946.Google Scholar
  5. Hofman, A.: Chemical aspects of psilocybin, the psychotropic principle from the Mexican fungus, Psilocybe mexicana Heim. Paper, presented at First Internat. Meeting of Neuro-Psycho-Pharmacology, Rome (Italy) Sept. 8–13, 1958.Google Scholar
  6. —, R. Heim, A. Brack u. H. Kobel: Psilocybin, ein psychotroper Wirkstoff aus dem mexikanischen Rauschpilz Psilocybe mexicana Heim. Experientia (Basel) 14, 107–109 (1958a).Google Scholar
  7. —, R. Heim, A. Brack, H. Kobel, A. Frey, H. Ott, T. H. Petrzilka u. E. Troxler: Konstitutionsaufklärung und Synthese von Psilocybin. Experientia (Basel) 14, 397–399 (1958b).Google Scholar
  8. Isbell, H., R. E. Belleville, H. F. Fraser, A. Wikler and C. R. Logan: Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication. A. M. A. Arch. Neurol. Psychiat. 76, 468–478 (1956).Google Scholar
  9. —, R. E. Belleville, H. F. Fraser, A. Wikler, C. R. Logan, C. R. Logan and E. J. Miner: Studies on lysergic acid diethylamide (LSD-25). III. Attempts to attenuate the LSD-reaction in man by pretreatment with neurohumoral blocking agents. A. M. A. Arch. Neurol Psychiat. 81, 20–27 (1959).Google Scholar
  10. Wasson, V. P., and R. G. Wasson: Mushrooms, Russia and History. New York: Pantheon Books 1957.Google Scholar
  11. Wilcoxon, F.: Some rapid approximate statistical procedures. New York: American Cyanamid Co. 1949.Google Scholar
  12. Winter, C. A., and L. Flataker: Studies on heptazone (6-Morpholino-4,4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic drugs. J. Pharmacol. exp. Ther. 98, 305–317 (1950).Google Scholar

Copyright information

© Springer-Verlag 1959

Authors and Affiliations

  • Harris Isbell
    • 1
  1. 1.National Institute of Mental Health, Addiction Research CenterU. S. Public Health ServiceLexington

Personalised recommendations