Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)
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The psychotomimetic potency of 13 congeners of LSD-25 has been approximately determined in man.
With the exception of acetylation of the indole nitrogen, all the changes made in the LSD molecule reduced psychotomimetic potency. Bromination at carbon 2 caused the greatest inactivation.
High potency as a serotonin antagonist in isolated smooth muscle preparations was not correlated with high potency as a psychotomimetic.
The data do not support but do not disprove the “serotonin deficiency” hypothesis of the LSD psychosis.
KeywordsNitrogen Smooth Muscle Serotonin Indole High Potency
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