The effects of psychotomimetic drugs on primary suggestibility
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Mescaline, LSD-25, psilocybin, and a combination of these three drugs were each administered in moderate doses at 7-day intervals to 24 volunteer subjects according to a latin square design. Primary suggestibility, that type closely related to hypnosis, was measured both before and 2 hrs following each administration of drugs, using the 17-item Stanford Suggestibility Scale. A Trance Indicator Score was also obtained, representing both behavioral observations and subjective reports concerning the degree of trance-like or hypnotic-like experiences which may have accompanied each suggestibility testing session.
Major findings were that mescaline, LSD-25, and the combination of drugs each produced an average enhancement in primary suggestibility closely comparable to that produced by an induction of hypnosis, the latter being tested for each subject after the completion of the drug series. Psilocybin did not enhance primary suggestibility. Associated trance phenomena were also substantially increased during all of the drug trials, but significantly less so for psilocybin. Significant correlations were obtained between suggestibility and Trance Indicator Scores following each drug and after induction of hypnosis, although psilocybin produced substantially less correlation.
Although these results confirm speculations previously made in the literature that LSD-25 may increase suggestibility, it must be emphasized that they cannot be generalized beyond the specific type of suggestibility measured. Second, the differences between psilocybin and the other drugs on primary suggestibility restrict generalizations regarding the action of otherwise similar psychotomimetic drugs.
KeywordsTesting Session Behavioral Observation Subjective Report Drug Trial Moderate Dose
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- Abramson, H. A. (Ed.): The Use of LSD in Psychotherapy. New Jersey: Josiah Macy jr. Foundation 1960.Google Scholar
- Alexander, L.: Differential effects of the new “psychotropic” drugs. Ann. N.Y. Acad. Sci. 67, 758–765 (1957).Google Scholar
- Baernstein, L. N.: An experimental study of the effect on waking suggestibility of small doses of scopolamine hydrobromide. Unpublished Master's Thesis, University of Wisconsin 1929.Google Scholar
- Cohen, M. E., and S. Cobb: The use of hypnosis in the study of acid-base balance of the blood in a patient with hysterical hyperventilation. Res. Publ. Ass. nerv. ment. Dis. 19, 318–332 (1939).Google Scholar
- Duncan, D. B.: Multiple range and multiple F tests. Biometrics 11, 1–42 (1955).Google Scholar
- Edwards, A. L.: Experimental Design in Psychological Research. New York: Holt, Rinehart and Winston 1960.Google Scholar
- Eysenck, H. J., and W. L. Rees: States of heightened suggestibility: Narcosis. J. ment. Sci. 91, 301–310 (1945).Google Scholar
- Fogel, S., and A. Hoffer: The use of hypnosis to interrupt and to reproduce an LSD-25 experience. J. clin. exp. Psychopath. 23, 11–16 (1962).Google Scholar
- Halpern, S., and S. Merlis: Hypnosis and psychotropic agents: Their interaction in mental patients. In Neuro-Psychopharmacology, Vol. 2, Rothlin, E. (Ed.). Amsterdam: Elsevier Publishing Co. 1961.Google Scholar
- Hollister, L. E.: Clinical, biochemical and psychologic effects of psilocybin. Arch. int. Pharmacodyn. 130, 42–52 (1961).Google Scholar
- —, and B. M. Sjoberg: Clinical syndromes and biochemical alterations following mescaline, lysergic acid diethylamide, psilocybin and a combination of the three psychomimetic drugs. Comprehens. Psychiat. 5, 170–178 (1964).Google Scholar
- Horsley, J. S.: Narco-analysis. New York: Oxford Univ. Press 1943.Google Scholar
- Hull, C. L.: Hypnosis and Suggestibility: An Experimental Approach. New York: Appleton-Century-Crofts 1933.Google Scholar
- Levine, J., A. M. Ludwig, and W. H. Lyle jr.: The controlled psychedelic state. Amer. J. clin. Hypn. 6, 163–164 (1963).Google Scholar
- Miller, G. A., E. Galanter, and K. H. Pribram: Plans and the Structure of Behavior. New York: Henry Holt and Co. 1960.Google Scholar
- Sargent, W., and E. Slater: An Introduction to Physical Methods of Treatment in Psychiatry. Baltimore: Williams and Williams Co. 1963.Google Scholar
- Schilder, P., and O. Kauder: Hypnosis. Nerv. and ment. Dis. Monogr. Ser. 46 (1927).Google Scholar
- Siegel, S.: Nonparametric Statistics. New York: McGraw-Hill 1956.Google Scholar
- Simko, A.: Suggestion and hypnosis therapy potentiated with Itridal. Med. Welt 32, 1606–1609 (1963).Google Scholar
- Starkey, F. R.: Ether hypnosis in psychotherapy. Med. J. Rec. 91, 631 (1917).Google Scholar
- Stukat, K. G.: Suggestibility: A Factorial and Experimental Analysis. Acta Psychologica Gothoburgensia, II. Stockholm: Almquist and Wiksell 1958.Google Scholar
- West, L. J.: Round Table Meeting on Current Practices in Hypnosis. 112th. Ann. Meeting Am. Psychiat. Assoc. Chicago 1956.Google Scholar
- Weitzenhoffer, A. M.: Hypnotism: An Objective Study in Suggestibility. New York: Wiley 1953.Google Scholar
- - Trance and trance-like states. A commentary on trance states in general and on the Balinese trance in particular. Unpublished Manuscript (1963).Google Scholar
- —, and E. R. Hilgard: Stanford Hypnotic Susceptibility Scale. Palo Alto: Gonsulting Psychologists Press 1959.Google Scholar
- — and B. M. Sjoberg: Suggestibility with and without “induction of hypnosis”. J. nerv. ment. Dis. 132, 204–220 (1961).Google Scholar