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Hornhauttrübungen durch Chloracetophenon

Corneal damage by chloracetophenon

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Chloracetophenone solubilized in 1,1,1-trichlorethan was applied in different concentrations to the rabbit cornea. Applications were made to the centre of the cornea as well as to the limbal area and also in an experiment with centrallimbal burning. The ensuming stromal scarring was related to the absolute quantity of applied chloracetophenone, and burning of the limbal area seemed to be more effective than central applications.


Chloracetophenon gelöst in 1,1,1-Trichloräthan wurde in unterschiedlichen Konzentrationen auf die Kaninchenhornhaut gegeben. Die Applikation erfolgte sowohl im Zentrum der Hornhaut, am Limbus bzw. zentral-limbal. Die entstehenden stromalen Hornhauttrübungen wurden bis zum 21. Tag kontrolliert. Weitere Untersuchungen weisen darauf hin, daß ausschließlich die Absolutmenge des applizierten Chloracetophenons den Grad des Schadens bestimmt, dabei wirkt sich die Verätzung des Limbus in besonders gravierender Weise aus.

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Bleckmann, H., Sommer, C. Hornhauttrübungen durch Chloracetophenon. Albrecht von Graefes Arch. Klin. Ophthalmol. 216, 61–67 (1981). https://doi.org/10.1007/BF00407778

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