Psychopharmacologia

, Volume 23, Issue 4, pp 348–356 | Cite as

Effects of atropine sulphate on repeated extinction performance in hippocampectomized rats

  • David M. Warburton
Animal Studies
Received:
Revised:

Abstract

Hippocampectomized and partially neodecorticated rats were trained on repeated extinction until similar baselines were obtained. Identical doses of atropine sulphate were administered to each group and the dose-response curves compared. The partially neodecorticated rats showed a marked increase in responding during the extinction periods and the magnitude of the effect increased with dose as in intact animals. The hippocampectomized animals showed little change in responding with any dose. The attenuation of the dose-response effect, in conjunction with other evidence, was consistent with the hypothesis of a second system which mediates response control in the hippocampectomised animals and is not cholinosensitive.

Key words

Atropine Sulphate Repeated Extinction Cholinergic System Hippocampus Stimulus Selection 
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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • David M. Warburton
    • 1
  1. 1.Department of PsychologyUniversity of ReadingEngland

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