Advertisement

Habituation of a mammary aplastic carcinoma on diabetic conditions

  • K. Pavelić
  • I. Bašić
  • J. Pavelić
Original Papers Experimental Oncology

Summary

Hypoglycemia and hypoinsulinemia accompanied the i.m. growth of mammary aplastic carcinoma in CBA mice. In hosts rendered diabetic by means of alloxan, the tumor decreased blood glucose levels to almost the level seen in non-diabetic mice. Tumors maintained in diabetic mice grew faster after each subsequent transplantation into diabetic mice, and we noted increased incorporation of 3H-thymidine into DNA of these tumor cells. The observed proliferation enhancement of mammary aplastic carcinoma maintained in diabetic mice is caused by de novo insulin and glucagon synthesis, apparently by the tumor cells themselves.

Key words

Mammary carcinoma Diabetes Habituation Insulin Glucagon 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bašić I, Varga E (1979) Immunogenicity of mammary carcinoma and a fibrosarcoma of CBA mice. Period Biol 81: 335–337Google Scholar
  2. Burton K (1956) A study of the conditions and mechanism of the dyphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62: 315–323Google Scholar
  3. Chowdhury F, Bleicher SJ (1973) Studies of tumor hypoglycemia. Metabolism 22: 663–674Google Scholar
  4. Goranson E S, Tilser G J (1955) Studies on the relationship of Alloxan-diabetes and tumor growth. Cancer Res 15: 626–631Google Scholar
  5. Hyvarinen A, Nikkila EA (1962) Specific determination of blood glucose with θ-toluidine. Clin Chim Acta 7: 140–143Google Scholar
  6. Jehl, JA, Mayer J, McKee RW (1955) Influence of the hereditary obese hyperglycemic syndrome and of Alloxan-diabetes on the survival of mice with Ehrlich ascites carcinoma. Cancer Res 15: 341–343Google Scholar
  7. Morgan C R, Lazarow A (1963) Immunoassay of insulin; two antibody system. Plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 12: 115–121Google Scholar
  8. Pavelić K, Slijepčević M (1978) Growth of a thymoma in diabetic mice treated with insulin. Eur J Cancer 14: 675–679Google Scholar
  9. Pavelić K (1979) Aplastic carcinoma in diabetic mice: Hyperglycemia-suppressed proliferation rate and insulin synthesis by tumor cells. J Natl Cancer Inst 62: 139–141Google Scholar
  10. Pavelić K, Slijepcevic M, Pavelić J, Ivić J, Audy-Jurkovic S, Pavelić ZP, Boranić M, Growth and treatment of Ehrlich tumor in mice with alloxan-induced diabetes. Cancer Res 39:1807–1813Google Scholar
  11. Puckett C L, Shingleton W W (1972) The effect of induced diabetes on experimental tumor growth in mice. Cancer Res 32: 789–790Google Scholar
  12. Rerup C C (1968) Spontaneous remission of alloxan diabetes in mice. Diabetologia 4: 312–318Google Scholar
  13. Shapot V S (1972) Some biochemical aspects of the relationship between the tumor and the host. Adv Cancer Res 15: 253–286Google Scholar
  14. Shima K, Foa P P (1968) A double antibody assay for glucagon. Clin Chim Acta 22: 511–520Google Scholar
  15. Todaro G, De Larco J E, Nissley S P, Rechler M M (1977) MSA and EGF receptors on sarcoma virus transformed cells and human fibrosarcoma cells in culture. Nature 267: 526–528Google Scholar
  16. Weber M J (1973) Hexose transport in normal and in Rous sarcoma virus-transformed cells. J Biol Chem 248: 2978–2983Google Scholar
  17. Welsch C W, Delturri G C, Brennan M J (1976) DNA synthesis of human, mouse and rat mammary carcinomas in vitro. Cancer 38: 1272–1281Google Scholar
  18. Woods M (1963) Hormonal control of metabolism in cancer. In: Wright E (ed) Control mechanisms in respiration and fermentation. Roland Press, New York pp 253–264Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • K. Pavelić
    • 1
  • I. Bašić
    • 2
  • J. Pavelić
    • 1
  1. 1.Department of Experimental Biology and MedicineRudjer Bošković InstituteZagrebCroatia, Yugoslavia
  2. 2.Department of Animal PhysiologyFaculty of Natural Sciences and MathematicsZagrebCroatia, Yugoslavia

Personalised recommendations