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The effect of strychnine sulphate on the home cage activity and oxygen consumption in three inbred strains of mice

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The home-cage activity of three inbred strains of mice was observed as a function of dosage of strychnine sulphate. Five kinds of activity were measured, but generally the drug effect was clear only for the sum of the measures. The effect of increasing dosage was to linearily reduce the activity measured. Oxygen uptake of the mice was recorded during the period that activity was scored, and it was found that the oxygen consumption did not decrease with increasing dosage as did overt activity, but in fact increased for two of the strains.

The general conclusions was that strychnine does reduce home-cage activity in mice, but that this change is probably not a necessary condition for effects of the drug on learning.

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This research was done in partial fulfillment of the requirements for the Ph.D. at the University of California, Berkeley, and was supported in part by Fellowships MPM-15, 878 and F1 MN-15,878-02 awarded by the National Institute of Mental Health, United States Public Health Service. Special appreciation goes to Gerald E. McClearn.

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Calhoun, W.H. The effect of strychnine sulphate on the home cage activity and oxygen consumption in three inbred strains of mice. Psychopharmacologia 8, 227–234 (1965). https://doi.org/10.1007/BF00405020

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  • Oxygen
  • Sulphate
  • Cage
  • Oxygen Consumption
  • Oxygen Uptake