Psychopharmacologia

, Volume 16, Issue 5, pp 409–418 | Cite as

Effect of diethyldithiocarbamate on the toxicity of amphetamine in aggregated mice

  • E. Przegalinski
  • Z. Kleinrok
Original Investigations
Received:

Summary

These studies were performed to investigate the influence of diethyldithiocarbamate on the toxicity of amphetamine in aggregated mice. In the same mice changes in body temperature and spontaneous motility were determined. In the other experiments brain catecholamine concentrations were assayed. Diethyldithiocarbamate potentiated the toxicity of amphetamine in some experimental conditions and slightly antagonized it in others. These effects are discussed in relation to behavioral and biochemical changes observed in mice.

Key-Words

Diethyldithiocarbamate Amphetamine Toxicity Behaviour Catecholamines 
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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • E. Przegalinski
    • 1
  • Z. Kleinrok
    • 1
  1. 1.Department of PharmacologySchool of MedicineLublinPoland

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