Journal of Cancer Research and Clinical Oncology

, Volume 112, Issue 2, pp 177–179 | Cite as

Enhancing effects of rodent malaria on aflatoxin B1-induced hepatic neoplasia

  • S. Angsubhakorn
  • P. Sathiropas
  • N. Bhamarapravati
Short Communication

Summary

The interaction between aflatoxin and malaria was tested for its usefulness as a model for hepatic tumor induction in rats. Male Buffalo rats which received aflatoxin B1 (AFB1) followed by Plasmodium berghei infection developed more preneoplastic lesions in the liver compared to those given AFB1 alone. No preneoplastic lesions were found in the liver of control and malarial-treated animals. These findings suggest that the malarial parasite facilitates liver tumor development initiated by AFB1 in rats.

Key words

Liver cancer Aflatoxin Malaria Rat 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • S. Angsubhakorn
    • 1
  • P. Sathiropas
    • 2
  • N. Bhamarapravati
    • 3
  1. 1.Department of Pathobiology, Faculty of ScienceMahidol UniversityBangkokThailand
  2. 2.Department of Clinical Microscopy, Faculty of Medical TechnologyKhon-Khaen UniversityKhon KhaenThailand
  3. 3.Department of Pathology, Faculty of Medicine, Ramathibodi HospitalMahidol UniversityBangkokThailand

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