Fluorescent lighting enhances chemically induced papilloma formation and increases susceptibility to tumor challenge in mice
Original Papers Experimental Oncology
To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation.
In experiment A the animals were irradiated for 6 weeks prior to the application of 7,12-dimethyl-benzanthracene once and — following an interval of 2 days for 10 weeks after DMBA application. The number of blue nevi and papillomas was enhanced by exposure to all spectra 10 weeks after chemical tumor induction.
In experiment B the animals were irradiated for 6 weeks prior to the transplantation of UV-induced fibrosarcoma cells from syngeneic mice into the dorsal and ventral skin. Within the following 4 months fibrosarcoma developed in the dorsal skin exposed to the fluorescent lighting and to the UVB radiation, as well as in the non-irradiated ventral skin of 10–20% of the mice.
The results suggest that fluorescent lighting as used in certain work environments may increase carcinogenesis caused by other factors.
Key wordsSkin cancer Fluorescent lighting Immune surveillance
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