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Journal of Cancer Research and Clinical Oncology

, Volume 112, Issue 2, pp 141–143 | Cite as

Fluorescent lighting enhances chemically induced papilloma formation and increases susceptibility to tumor challenge in mice

  • A. Wiskemann
  • E. Sturm
  • N. W. Klehr
Original Papers Experimental Oncology

Summary

To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation.

In experiment A the animals were irradiated for 6 weeks prior to the application of 7,12-dimethyl-benzanthracene once and — following an interval of 2 days for 10 weeks after DMBA application. The number of blue nevi and papillomas was enhanced by exposure to all spectra 10 weeks after chemical tumor induction.

In experiment B the animals were irradiated for 6 weeks prior to the transplantation of UV-induced fibrosarcoma cells from syngeneic mice into the dorsal and ventral skin. Within the following 4 months fibrosarcoma developed in the dorsal skin exposed to the fluorescent lighting and to the UVB radiation, as well as in the non-irradiated ventral skin of 10–20% of the mice.

The results suggest that fluorescent lighting as used in certain work environments may increase carcinogenesis caused by other factors.

Key words

Skin cancer Fluorescent lighting Immune surveillance 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • A. Wiskemann
    • 1
  • E. Sturm
    • 1
  • N. W. Klehr
    • 2
  1. 1.Section of Dermatologic Radiology, HamburgUniversity HospitalHamburg 20Federal Republic of Germany
  2. 2.TraunsteinFederal Republic of Germany

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