Psychopharmacologia

, Volume 20, Issue 2, pp 169–171 | Cite as

Exploratory behavior in chronic disulfoton poisoning in mice

  • George Clark
  • Anna G. Koester
  • David W. Pearson
Animal Studies

Abstract

The behavior of four groups of white mice was compared using the “hole-board” test. One male and one female group were chronically poisoned with disulfoton while similar untreated male and female groups served as controls. The scores of the poisoned animals were significantly higher than those of the controls, indicating that the poisoned animals exhibited increased exploratory behavior. There were no sex differences.

Key-Words

Exploratory Behavior Disulfoton Acetylcholinesterase Sex 

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References

  1. Boissier, J. R., Simon, P., Lwoff, J. M.: L'utilization d'une reaction particulière de la souris (méthode de la planche a trous) pour l'étude des médicamentes psychotropes. Thérapie 19, 57–1589 (1964).Google Scholar
  2. Clark, George, Pearson, D. W.: In preparation (1970).Google Scholar
  3. - Stavinocha, W. H.: In preparation (1970).Google Scholar
  4. Pearson, D. W., Clark, George, Moore, C. M.: Comparison of behavioral effects of various levels of chronic Di-Syston Poisoning. Proceedings, 77th Annual Convention, APA, pp. 871–872 (1969).Google Scholar
  5. Valzelli, L.: The exploratory behaviour in normal and aggressive mice. Psychopharmacologia (Berl.) 15, 232–235 (1969).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • George Clark
    • 1
    • 2
    • 3
    • 4
  • Anna G. Koester
    • 1
    • 2
    • 3
    • 4
  • David W. Pearson
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of AnatomyMedical University of South CarolinaCharleston
  2. 2.Veterans Administration HospitalCharleston
  3. 3.Department of Human Ecology, School of HealthUniversity of OklahomaOklahoma City
  4. 4.Rohrer, Hibler and ReplogleDallas

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