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Individual differences in serum levels of lithium in human subjects receiving fixed doses of lithium carbonate. relation to renal lithium clearance and body weight

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Serum levels of lithium were determined in ten healthy subjects receiving a fixed dose regimen of lithium carbonate for eight days. A steady state level of the morning serum lithium concentration was obtained after 6 to 8 days, and this level varied up to 3-fold between subjects. The lithium levels in serum were significantly correlated with the renal lithium clearances (p<0.05). There was a highly significant correlation (p<0.001) between the steady state level and the product of lithium clearance and body weight. No correlation was found between renal lithium and creatinine clearances.

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Sedvall, G., Pettersson, U. & Fyrö, B. Individual differences in serum levels of lithium in human subjects receiving fixed doses of lithium carbonate. relation to renal lithium clearance and body weight. Pharmacol. Clin. 2, 231–235 (1970). https://doi.org/10.1007/BF00404306

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  • Body Weight
  • Steady State
  • Lithium
  • Creatinine
  • Serum Level