Pharmacologia Clinica

, Volume 2, Issue 4, pp 196–199 | Cite as

A program for the simulation of multiple dosage regimens on an analog computer

  • H. M. von Hattingberg
Original
Received:

Summary

Small general purpose analog computers are not usually equipped for iterative computation. Since multiple dosage problems are often encountered in pharmacokinetic studies an approximating program is proposed for rapid estimation and curve fitting. The program produces an input function simulating a staircase by integration only of the positive differentials of a sequence of rectangular impulses. The program is used to compute the maximum and minimum concentration factors of Sparteine and Quinidine as examples of two substances obeying first order kinetics. It is apparent from the results that the choice of dosage schedules is restricted both by the pharmacological and the pharmacokinetic properties of the drugs.

Keywords

Quinidine Multiple Dosage Pharmacokinetic Property Analog Computer Concentration Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Literature

  1. 1.
    Dengler, H. J., Eichelbaum, M., Hengstmann, J., Wieber, J.: Pharmacokinetic studies in man with spartein. Pharmacol. Clin. 2, 189–195 (1970).Google Scholar
  2. 2.
    Dengler, H. J., Dieterich, K., Schüttrumpf, G.: to be published.Google Scholar
  3. 3.
    Dost, F. H., Repges, R.: Zur Beschreibung der Pharmakokinetik der Bromsulphalein-Ausscheidung unter Verwendung des Analog-Computers. Pharmacol. Clin. 1, 1 (1968).Google Scholar
  4. 4.
    Garrett, E. R., Thomas, R. C., Wallach, D. P., Alway, C. D.: Psicofuranine, kinetics and mechanisms in vivo with the application of the analogue computer. J. Pharmacol. exp. Ther. 130, 106 (1960).Google Scholar
  5. 5.
    Giloi, W., Herschel, R.: Rechenanleitung für Analogrechner. Allgemeine Elektrizitätsgesellschaft AEG-Telefunken, Konstanz.Google Scholar
  6. 6.
    Randall, J.E.: The analog computer in the biological laboratory. In Computers in biomedical research. Stacy, R. W., Waxman, B. D., (Editors). New York and London: Academic Press 1965.Google Scholar
  7. 7.
    Röpke, H., Riemann, J.: Analogcomputer in Chemie und Biologic. Berlin: Springer 1969.Google Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • H. M. von Hattingberg
    • 1
  1. 1.Department of Pediatrics Justus Liebig UniversityGiessenGermany

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