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Archives of Dermatological Research

, Volume 268, Issue 3, pp 271–276 | Cite as

Lipid synthesis from the liver in patients with psoriasis

  • G. Mingrone
  • A. V. Greco
  • A. Venier
  • E. Peruzzi
  • F. Serri
Original Contributions

Summary

In psoriatic patients with hyperlipidemia we studied the hepatic lipidic synthesis from (1-14C)-acetate in human liver biopsy specimens in vitro by a thin-layer radio-chromatography.

In psoriatics type IV (according to Fredrickson) a significant increase in (1-14C)-acetate hepatic incorporation especially into phospholipids (25%) and triglycerides (52%) was observed; in type IIb increased lipogenesis was accompanied by a greater hepatic incorporation of labelled acetate into phospholipids (24.5%), free cholesterol (44.4%) and triglycerides (29%).

Abnormal lipid metabolism often coexists with glucose intolerance in psoriasis; no correlation between hyperinsulinemia and augmented (1-14C)-acetate incorporation into hepatic triglycerides was found.

Key words

Hyperlipoproteinemia Psoriasis Lipidic synthesis (1-14C)-Acetate 

Zusammenfassung

Bei psoriatischen Patienten mit Hyperlipidämie wurde die hepatische Lipidsynthese mittels (1-14C)-Acetat in menschlichen Leberschnitten in vitro mittels Dünnschichtradiochromatographie bestimmt. Bei Psoriatikern mit einer Hyperlipidämie Typ IV wurde eine signifikante Vermehrung des Einbaus von (1-14C)-Acetat in der Leber, besonders von Phospholipiden und Triglyceriden beobachtet. In Typ II b war die vermehrte Lipogenese mit einer erhöhten Aufnahme in der Leber in Phospholipide (24,5%), freiem Cholesterol (44,4%) und Triglyceriden (29,0%) verbunden. Abnormaler Fettstoffwechsel kombiniert sich häufiger mit einer Glucoseintoleranz bei der Psoriasis. Es wurde keine Korrelation zwischen Hyperinsulinämie und vermehrtem (1-14C)-Acetat-Einbau in hepatische Triglyceride gefunden.

Schlüsselwörter

Hyperlipidproteinämie Psoriasis Lipidsynthese (1-14C)-Acetat 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • G. Mingrone
    • 1
  • A. V. Greco
    • 1
  • A. Venier
    • 2
  • E. Peruzzi
    • 1
  • F. Serri
    • 2
  1. 1.Department of Internal MedicineUniversità CattolicaRomaItaly
  2. 2.Department of DermatologyUniversità CattolicaRomaItaly

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