Psychopharmacologia

, Volume 7, Issue 1, pp 57–60 | Cite as

Drug effects and initial severity of symptomatology

  • Seymour Fisher
  • Ronald S. Lipman
  • E. H. Uhlenhuth
  • Karl Rickels
  • Lee C. Park
Original Investigations

Summary

A recurring question appearing in clinical psychopharmacological research concerns the nature of the relationship between initial severity of symptomatology and the magnitude of a drug effect. Data are presented to show that, with meprobamate and placebo in neurotic outpatients, the magnitude of the pharmacological effect remains constant across all levels of initial severity.

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References

  1. Benjamin, L. S.: Statistical treatment of the Law of Initial Values (LIV) in autonomic research: a review and recommendation. Psychosom. Med. 25, 556–566 (1963).PubMedGoogle Scholar
  2. Fisher, S., J. O. Cole, K. Rickels, and E. H. Uhlenhuth: Drug-set interaction: the effect of expectations on drug response in outpatients. Proceedings of the Third Collegium Internationale Neuropsychopharmacologicum (in press).Google Scholar
  3. Gliedman, L. H., E. H. Nash, S. D. Imber, A. R. Stone, and J. D. Frank: Reduction of symptoms by pharmacologically inert substances and by short-term psychotherapy. Arch. Neurol. Psychiat. 79, 345–351 (1958).Google Scholar
  4. Snedecor, G. W.: Statistical Methods, p. 394–400. Iowa State College Press 1956.Google Scholar

Copyright information

© Springer-Verlag 1965

Authors and Affiliations

  • Seymour Fisher
    • 1
    • 2
  • Ronald S. Lipman
    • 1
    • 2
  • E. H. Uhlenhuth
    • 1
    • 2
  • Karl Rickels
    • 1
    • 2
  • Lee C. Park
    • 1
    • 2
  1. 1.Boston University Medical Center, the National Institute of Mental HealthJohns Hopkins UniversityUSA
  2. 2.University of PennsylvaniaUSA

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