Psychopharmacologia

, Volume 23, Issue 3, pp 289–299

Effect of Δ9-THC on the open-field activity of the rat

  • Wm. G. Drew
  • Loren L. Miller
  • A. Wikler
Original Investigations Animal Studies

DOI: 10.1007/BF00404134

Cite this article as:
Drew, W.G., Miller, L.L. & Wikler, A. Psychopharmacologia (1972) 23: 289. doi:10.1007/BF00404134

Abstract

Using the open-field activity of the hooded rat as a model of overall activity, the dose-response and time-action effects of doses of Δ9-THC which did not adversely affect spontaneous activity or behavior on appetitively motivated tasks were studied. Subjects received two exposures to an open field one week apart. Prior to the first exposure subjects were treated with small doses of Tween 80-water. At 30 min or 3 h prior to the second exposure subjects were treated with Tween or Δ9-THC in doses which ranged from 0.5–5 mg/kg. Results indicated that Δ9-THC affected various indices of open-field activity such as grooming, sniffing and ambulation differently depending on the time after injection. Rearing and defecation were affected similarly by THC independent of post-injection intervals.

Key words

Δ9-Tetrahydrocannabinol Open-Field Activity Dose-Response Time-Action Rats Emotionality Tween 80 

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Wm. G. Drew
    • 1
  • Loren L. Miller
    • 1
  • A. Wikler
    • 1
  1. 1.Laboratories of Behavioral Neurophysiology, Department of PsychiatryUniversity of Kentucky, College of MedicineLexingtonUSA

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