Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Traitement prolongé à la morphine chez le rat: interaction drogue/comportement dans des conditionnements sous contrôle aversif

Prolonged treatment with morphine in rats: Drug/behavior interaction under aversive control

  • 18 Accesses

  • 4 Citations


Four rats were conditioned alternately on a titration schedule and on a Sidman avoidance schedule, without warning stimulus, in a circular box. Morphine (15 mg/kg daily) was administered for 30 consecutive days, and again for 4 days after 22 sessions of conditioning without drugs. In a circular box, the excitation induced by morphine showed a slow daily decrease suggesting development of tolerance. In the titration schedule, responding was depressed by the drug. After a few days, the rate of responding increased and the depression was reversed to excitation. When the drug was withdrawn, the rats showed a pattern of behaviour close to the normal baseline. The same effects appeared when morphine was injected after 6 weeks interruption of treatment.

This is a preview of subscription content, log in to check access.


  1. Dallemagne, Gh.: Etude de l'action des analgésiques sur deux comportements d'évitement chez le rat. Psychol. Belg. 8, 103–114 (1968).

  2. —, Richelle, M.: Titration schedule with rats in a restraining device. J. exp. Anal. Behav. 13, 339–348 (1970).

  3. Djahanguiri, B., Richelle, M., Fontaine, O.: Behavioral effects of a prolonged treatment with small doses of morphine in cats. Psychopharmacologia (Berl.) 9, 363–372 (1966).

  4. McMillan, D. E., Morse, W. H.: Some effects of morphine and morphine antagonists on schedule-controlled behavior. J. Pharmacol. exp. Ther. 157, 175–184 (1967).

  5. Richelle, M., Joiris, D., Ourth, H., Perikel, J. J.: Action différentielle de l'amphétamine sur une conduite locomotrice spontanée et conditionnée chez le rat. J. Physiol. (Paris) 59, 481 (1968).

  6. Thompson, T., Trombley, J., Luke, D., Lott, D.: Effects of morphine on behavior maintained by four simple food-reinforcement schedules. Psychopharmacologia (Berl.) 17, 182–192 (1970).

  7. Weiss, B., Laties, V. C.: Fractional escape and avoidance on a titration schedule. Science 128, 1575 (1958).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dallemagne, G. Traitement prolongé à la morphine chez le rat: interaction drogue/comportement dans des conditionnements sous contrôle aversif. Psychopharmacologia 20, 77–84 (1971). https://doi.org/10.1007/BF00404061

Download citation


  • Aversive Conditionings
  • Rats
  • Morphine
  • Tolerance