Psychopharmacologia

, Volume 21, Issue 1, pp 1–7

A simple and reliable conflict procedure for testing anti-anxiety agents

  • John R. Vogel
  • Bernard Beer
  • Donald E. Clody
Original Investigations Animal Studies

Abstract

The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital, d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water. The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital. Doses of d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide did not increase responding.

Key-Words

Benzodiazepines Minor Tranquilizers Conflict Anti-Anxiety Psychopharmacological Procedures 

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • John R. Vogel
    • 1
  • Bernard Beer
    • 1
  • Donald E. Clody
    • 1
  1. 1.The Squibb Institute for Medical ResearchNew Brunswick

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