A simple and reliable conflict procedure for testing anti-anxiety agents
- 480 Downloads
The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital, d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water. The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital. Doses of d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide did not increase responding.
Key-WordsBenzodiazepines Minor Tranquilizers Conflict Anti-Anxiety Psychopharmacological Procedures
Unable to display preview. Download preview PDF.
- Geller, I.: Use of approach avoidance (conflict) for evaluating depressant drugs. In: J. H. Nodine and J. H. Moger (Eds.): Psychosomatic Medicine, pp. 267–281. Philadelphia: Lea and Febiger 1962.Google Scholar
- —, Kulak, J. T., Seifter, J.: The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination. Psychopharmacologia (Berl.) 3, 374–385 (1962).Google Scholar
- —, Seifter, J.: The effects of meprobamate, barbiturates, d-amphetamine, and promazine on experimentally induced conflict in the rat. Psychopharmacologia (Berl.) 1, 482–492 (1960).Google Scholar
- Hanson, H. M., Stone, C. A.: Animal techniques for evaluating anti-anxiety drugs. In: J. H. Nodine and P. E. Siegler: Animal and clinical pharmacologic techniques in drug Evaluation, pp. 317–324. Chicago: Yearbook Medical Publishers 1964.Google Scholar
- Miller, N. E.: Some recent studies of conflict behavior and drugs. Amer. Psychologist 16, 12–24 (1961).Google Scholar