The effects of levallorphan and cyprenorphine (M 285) were studied on repeated Y-maze performance in rats. It was postulated that these narcotic antagonists—implicated as psychotomimetics—would disrupt the experiencing process and augment fear-motivated behaviour. These compounds produced differential effects on behaviour. Levallorphan induced bizarre-excitation and disrupted habituation; cyprenorphine was ineffective in these respects. No augmentation of fear-motivated behaviour was observed. Amphetamine increased locomotor activity without affecting habituation.
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Wray, S.R., Cowan, A. The behavioural effects of levallorphan, cyprenorphine (M 285) and amphetamine on repeated Y-maze performance in rats. Psychopharmacologia 21, 257–267 (1971). https://doi.org/10.1007/BF00403864
- Narcotic Antagonist