Psychopharmacologia

, Volume 21, Issue 3, pp 257–267 | Cite as

The behavioural effects of levallorphan, cyprenorphine (M 285) and amphetamine on repeated Y-maze performance in rats

  • Samuel R. Wray
  • Alan Cowan
Original Investigations Animal Studies
Received:
Revised:

Abstract

The effects of levallorphan and cyprenorphine (M 285) were studied on repeated Y-maze performance in rats. It was postulated that these narcotic antagonists—implicated as psychotomimetics—would disrupt the experiencing process and augment fear-motivated behaviour. These compounds produced differential effects on behaviour. Levallorphan induced bizarre-excitation and disrupted habituation; cyprenorphine was ineffective in these respects. No augmentation of fear-motivated behaviour was observed. Amphetamine increased locomotor activity without affecting habituation.

Key-Words

Narcotic Antagonist Psychotomimetic Habituation Activity Stress 
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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Samuel R. Wray
    • 1
    • 2
  • Alan Cowan
    • 1
    • 2
  1. 1.Department of PsychologyUniversity of HullHullEngland
  2. 2.Department of PharmacologyReckitt and Colman LimitedHullEngland

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