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Lack of enhancement of experimental photocarcinogenesis by topical retinoic acid

Summary

A controversy exists regarding the ability of retinoic acid to enhance photocarcinogenesis. Divergent results have been obtained with albino hairless mice. We examined this issue with the lightly pigmented variety. We followed two designs: 1. ultraviolet light and topical retinoic acid were given concomitantly while the retinoic acid was continued for many weeks after stopping irradiation; 2. tumors were first induced by ultraviolet light and then treated topically with retinoic acid. In both studies, retinoic acid did not enhance photocarcinogenesis with regard to latent period, tumor yield or tumor progression. It appears that different treatment schedules and different varieties of mice can produce widely disparate results.

Zusammenfassung

Es herrscht Uneinigkeit über die Möglichkeit einer Steigerung der Photokarzinogenese durch Vitamin A-Säure. Verschiedenartige Ergebnisse wurden bei Untersuchungen an haarlosen Albinomäusen erzielt. Wir untersuchten diese Fragestellung an einer wenig pigmentierten Mäuseart. Dabei gingen wir nach zweierlei Untersuchungsplänen vor. 1. Es wurden gleichzeitig ultraviolettes Licht und Vitamin A-Säure appliziert, wobei die Vitamin A-Säure mehrere Wochen nach Beendigung der Bestrahlung weiterverabreicht wurde. 2.Zunächst wurden Tumoren durch ultraviolettes Licht induziert, danach örtlich mit Vitamin A-Säure behandelt. In beiden Studien steigerte Vitamin A-Säure im beobachteten Zeitraum nicht die Photokarzinogenese, die Tumorentstehungsrate und die Tumorprogression. Wie es scheint, führen verschiedenartige Behandlungsschemata und verschiedene Mausarten zu stark voneinander abweichenden Untersuchungsergebnissen.

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Kligman, L.H., Kligman, A.M. Lack of enhancement of experimental photocarcinogenesis by topical retinoic acid. Arch Dermatol Res 270, 453–462 (1981). https://doi.org/10.1007/BF00403790

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Key words

  • Photocarcinogenesis
  • Hairless mice
  • Retinoic Acid

Schlüsselwörter

  • Photokarzinogenese
  • haarlose Mäuse
  • Vitamin A-Säure