Archives of Dermatological Research

, Volume 274, Issue 3–4, pp 259–266 | Cite as

Studies on the immunologic aspects of keloids and hypertrophic scars

  • A. M. P. Janssen de Limpens
  • R. H. Cormane
Original Contributions

Summary

A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated.

All the 13 patients with keloids revealed in the eluates antinuclear antibodies belonging to one or more of the five main classes and directed mainly against fibroblasts. On the other hand, there were no antinuclear antibodies detectable in the eluates of the seven patients with hypertrophic scars and in over 40 healthy controls.

Key words

Keloids Hypertrophic scars Eluted ANA 

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References

  1. Bos Jd, Hamerlinck F, Cormane RH (1980) Immunoglobulin bearing lymphoid cells in primary syphilis. Br J Vener Dis 56:69–73PubMedGoogle Scholar
  2. Böyum A (1980) Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest [Suppl 97] 21:1–106Google Scholar
  3. Cohen IK, Keiser HR, Sjoerdsma A (1971) Collagen synthesis in human keloid and hypertrophic scar. Surg Forum 22:488–489PubMedGoogle Scholar
  4. Cohen IK, Diegelman RF, Bryant CP (1975) Alpha globulin collagenase inhibitors in keloid and hypertrophic scar. Surg Forum 26:61–62PubMedGoogle Scholar
  5. Cohen IK, McCoy BJ, Clore JN, Diegelman RF (1979) Proceedings VIIth Congress for Plastic and Reconstructive Surgery, Rio de Janeiro. Current findings regarding keloid pathogenesisGoogle Scholar
  6. Cormane RH, Hamerlinck F, Husz S (1974) Elution of antibodies from the lymphocyte membrane in certain dermatoses. Br J Dermatol 91:315–317PubMedGoogle Scholar
  7. Cormane RH, Hunyadi J, Hamerlinck F (1976) The role of lymphoid cells and polymorphonuclear leukocytes in the pathogenesis of psoriasis. J Dermatol 3:247–259Google Scholar
  8. Cormane RH, Hamerlinck F, Siddiqui AH (1979a) Immunologic implications of PUVA therapy in psoriasis vulgaris. Arch Dermatol Res 265:245–267PubMedGoogle Scholar
  9. Cormane RH, Hamerlinck F, Nunzi E (1979b) Antibodies eluted from the lymphoid cell membrane. Occurrence in certain varieties of scleroderma. Arch Dermatol 115:709–712CrossRefPubMedGoogle Scholar
  10. Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (1979) Dermatology in general medicine. McGraw Hill, New YorkGoogle Scholar
  11. Jordan RE, Nordby JM, Milstein H (1975) The complement system in bullous pemphigoid. III. Fixation of Clq and C3 by pemphigoid antibody. J Lab Clin Med 86:733–740PubMedGoogle Scholar
  12. Knapp TR, Daniels JR, Kaplan EN (1977) Pathologic scar formation. Am J Pathol 86:47–70PubMedGoogle Scholar
  13. Laurentaci G, Dioguardi D (1977) HLA antigens in keloids and hypertrophic scars. Arch Dermatol 113:1726PubMedGoogle Scholar
  14. Milson JP, Craig RDP (1973) Collagen degradation in cultured keloid and hypertrophic scar tissue. Br J Dermatol 89:635–644PubMedGoogle Scholar
  15. Nunzi E, Hamerlinck F, Cormane RH (1980) Immunopathologic studies on alopecia areata. Arch Dermatol Res 269:1–11PubMedGoogle Scholar
  16. Rook A, Wilkinson DS, Ebling FSG (1979) Textbook of dermatology. Blackwell, OxfordGoogle Scholar
  17. Russell JD, Witt W (1976) Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue. Plast Reconstr Surg 57:207–212PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. M. P. Janssen de Limpens
    • 1
  • R. H. Cormane
    • 1
  1. 1.Department of DermatologyAcademic Medical Center, University of AmsterdamAmsterdamThe Netherlands

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