Archives of Dermatological Research

, Volume 274, Issue 3–4, pp 259–266

Studies on the immunologic aspects of keloids and hypertrophic scars

  • A. M. P. Janssen de Limpens
  • R. H. Cormane
Original Contributions

DOI: 10.1007/BF00403728

Cite this article as:
Janssen de Limpens, A.M.P. & Cormane, R.H. Arch Dermatol Res (1982) 274: 259. doi:10.1007/BF00403728


A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated.

All the 13 patients with keloids revealed in the eluates antinuclear antibodies belonging to one or more of the five main classes and directed mainly against fibroblasts. On the other hand, there were no antinuclear antibodies detectable in the eluates of the seven patients with hypertrophic scars and in over 40 healthy controls.

Key words

Keloids Hypertrophic scars Eluted ANA 

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. M. P. Janssen de Limpens
    • 1
  • R. H. Cormane
    • 1
  1. 1.Department of DermatologyAcademic Medical Center, University of AmsterdamAmsterdamThe Netherlands

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