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Flurothyl toxicity: a remarkable species difference between chick and mouse

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Summary

Young chicks survive flurothyl vapor concentrations that are lethal to mice. For a 10-min exposure, the LD50 concentrations (% v/v) of flurothyl are 10.1% in chicks and 0.33% in mice; the convulsant concentrations (CD50) are 0.49% in chicks and 0.32% in mice. The remarkable resistance of young chicks to flurothyl toxicity may be related to their known resistance to hypoxic death.

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Cherkin, A. Flurothyl toxicity: a remarkable species difference between chick and mouse. Psychopharmacologia 15, 404–407 (1969). https://doi.org/10.1007/BF00403715

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Key-Words

  • Chicks
  • Convulsants
  • Flurothyl
  • Mice
  • Toxicology