Effects of imipramine on anxiety and hostility levels
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An initial longitudinal study of the psychologic effects of imipramine on one patient in which the active drug was alternated with a placebo, led to short term studies on four other subjects. A measure of emotional reaction was used which was derived from small samples of speech; it was demonstrated to be an objective and sensitive instrument for the detection of changes in anxiety and hostility.
While imipramine was consistently associated with an increase in the expression of hostility directed outward for the one patient, the increase in hostility outwards for four additional patients was not sufficiently great to reject, with conviction, the hypothesis of chance. However, these four other patients did show a significant increase in a subcategory of hostility directed outward, namely, overt hostility outward.
Imipramine, as compared to a placebo, significantly increased levels of anxiety in the verbal samples of the subjects tested.
No significant changes were noted with imipramine on scores of hostility directed inwards or ambivalently directed hostility, probably because none of these patients was clinically depressed.
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- Azima, H., and R. H. Vispo: Effects of imipramine (Tofranil) on depressive states: A clinical and psychodynamic study. Arch. Neurol. Psychiat. 81, 658–664 (1959).Google Scholar
- Blair, D.: Treatment of severe depression by imipramine (Tofranil): An investigation of 100 cases. J. ment. Sci. 106, 891–905 (1960).Google Scholar
- Chassan, J. B., and L. Bellak: An introduction to intensive design in the evaluation of drug efficacy in psychotherapy. In: Methods of Research in Psychotherapy. Gottschalk, L. A., and A. H. Auerbach (eds.). New York: Appleton-Century-Crofts 1965.Google Scholar
- - - and R. Fox: Immediate changes in anxiety and hostility with chlordiazepoxide administration in juvenile delinquent boys. (In preparation) (1965).Google Scholar
- Gottschalk, L. A., F. T. Kapp, W. D. Ross, S. M. Kaplan, H. Silver, J. H. MacLeod, J. B. Kahn, E. F. Van Maanen and G. H. Acheson: Explorations in testing drugs affecting physical and mental activity. J. Amer. med. Ass. 161, 1054–1058 (1956).Google Scholar
- —, and S. M. Kaplan: A quantitative method of estimating variations in intensity of a psychologic conflict or state. Arch. Neurol. Psychiat. (Chic.) 79, 688–696 (1958b).Google Scholar
- —, K. J. Springer, and G. C. Gleser: Experiments with a method of assessing the variations in intensity of certain psychological states occurring during two psychotherapeutic interviews. In: Comparative Psycholinguistic Analysis of Two Psychotherapeutic Interviews. Edited by Gottschalk, L. A. New York: International Universities Press 1961a.Google Scholar
- — —, Distinguishing characteristics of the verbal communications of schizophrenic patients. Proceedings of the Assn. for Research in Nerv. and Ment. Dis. on Disorders of Communication. Baltimore: Williams and Wilkins Co. 1964b.Google Scholar
- Ruskin, D., and R. D. Goldner: Treatment of depressions in private practice with imipramine. Dis. nerv. Syst. 20, 391–399 (1959).Google Scholar
- Whitman, R. M., M. Pierce, J. W. Maas, and B. Baldridge: Drugs and dreamsII: Imipramine and prochlorperazine. Comprehens. Psychiat. 2, 219–226 (1961).Google Scholar