A comparison of LSD-25 with (−)-Δ9-trans-tetrahydrocannabinol (THC) and attempted cross tolerance between LSD and THC
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Summary
- 1.
The objective and subjective effects of 0.5 and 1.5 mcg/kg of LSD intramuscularly were compared with those of 75 and 225 mcg/kg of (-)-Δ9-trans-tetrahydrocannabinol by smoking in the same eight subjects.
- 2.
The objective effects of LSD and THC differed markedly. LSD increased body temperature, systolic and diastolic blood pressure, lowered the threshold for the knee-jerk, and dilated the pupils. THC had none of these effects but caused more marked tachycardia than did LSD.
- 3.
The subjective effects of the two drugs could not be readily distinguished by the methods used. Both LSD and THC are psychotomimetic drugs.
- 4.
Patients tolerant to LSD were not cross-tolerant to THC, indicating that the mental effects of the two drugs are probably mediated by different mechanisms.
Key-Words
Cannabis Marihuana (−)-Δ9-TetrahydrocannabinoI Lysergic Acid Diethylamide LSD Tolerance LSD and THC Cross-TolerancePreview
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