Psychopharmacologia

, Volume 20, Issue 4, pp 307–314

Rubidium chloride ingestion by volunteer subjects: Initial experience

  • Ronald R. Fieve
  • Herbert L. Meltzer
  • Reginald M. Taylor
Original Investigations Human Pharmacology

Abstract

The authors report on the first metabolically controlled study of rubidium chloride administered to humans. Four subjects were given doses of 8.2–12.4 meq. RbCl in a single day, and biological half lives calculated from urinary excretion ranged from 21–55 days. A long term study of chronic rubidium loading in one of these subjects demonstrated no undesirable clinical side effects. After ingestion of a total dose of 268 meq. within a period of 75 days a plasma level of 0.16 meq./liter rubidium was obtained. Urinary excretion proceeded at a rate consistent with a 50 day half life.

The authors speculate on the potential usefulness of RbCl for modification of behavior and affect.

Key-Words

Rubidium Chloride Human Ingestion Metabolism Behavior Electrolyte 

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Ronald R. Fieve
    • 1
  • Herbert L. Meltzer
    • 1
  • Reginald M. Taylor
    • 1
  1. 1.N.Y. State Psychiatric InstituteUSA

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