, Volume 20, Issue 4, pp 307–314

Rubidium chloride ingestion by volunteer subjects: Initial experience

  • Ronald R. Fieve
  • Herbert L. Meltzer
  • Reginald M. Taylor
Original Investigations Human Pharmacology


The authors report on the first metabolically controlled study of rubidium chloride administered to humans. Four subjects were given doses of 8.2–12.4 meq. RbCl in a single day, and biological half lives calculated from urinary excretion ranged from 21–55 days. A long term study of chronic rubidium loading in one of these subjects demonstrated no undesirable clinical side effects. After ingestion of a total dose of 268 meq. within a period of 75 days a plasma level of 0.16 meq./liter rubidium was obtained. Urinary excretion proceeded at a rate consistent with a 50 day half life.

The authors speculate on the potential usefulness of RbCl for modification of behavior and affect.


Rubidium Chloride Human Ingestion Metabolism Behavior Electrolyte 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Botkin, S. S.: The influence of the salts of rubidium and cesium upon the heart and circulation in connection with the laws of physiological action of alkali metals. Doctoral Dissertation, St. Petersburg Military-Medical Academy, 1888 (Russian).Google Scholar
  2. 2.
    Colombini, P., Pasquini, P.: The action of rubidium iodide on the blood of syphilitics. Rif. med. 3, 387–389, 411–414 (1898) (Italian).Google Scholar
  3. 3.
    Fieve, R. R.: Multiple measures of behavior and metabolism in interdisciplinary research. Amer. Psych. Assoc. Meeting (Detroit), May 8–12, 1967).Google Scholar
  4. 4.
    —, Platman, S. R., Plutchik, R. R.: The use of lithium in affective disorders: I. Acute endogenous depression. Amer. J. Psychiat. 125, 487–491 (1968).Google Scholar
  5. 5.
    Iinuma, T., Watari, K., Nagai, T., Iwashima, K., Yamagata, N.: Comparative studies of 132Cs and 86Rb turnover in man using a double-tracer method. J. Radiat. Res. (Tokyo) 8, 100–115 (1967).Google Scholar
  6. 6.
    Kilpatrick, R., Renschler, H. E., Munro, D. S., Wilson, G. M.: A comparison of the distribution of 42K and 86Rb in rabbit and man. J. Physiol. (Lond.) 133, 194–201 (1956).Google Scholar
  7. 7.
    Laufenauer, K.: The therapeutic action of rubidium-ammonium-bromide. Orv. Hetil. 24, 317–319 (1889) (Hungarian).Google Scholar
  8. 8.
    Leistikov, L.: Rubidium iodide. Mh. prakt. Derm. 17, 509–510 (1893).Google Scholar
  9. 9.
    Meltzer, H. L., Taylor, R. M., Platman, S. R., Fieve, R. R.: Rubidium: A potential modifier of affect and behaviour. Nature (Lond.) 223, 321–322 (1969).Google Scholar
  10. 10.
    Ray, C. T., Threefoot, S. A., Burch, G. E.: The excretion of radiorubidium, Rb86, radiopotassium, K42, and potassium, sodium, and chloride by man with and without congestive heart failure. J. Lab. clin. Med. 45, 408–430 (1955).Google Scholar
  11. 11.
    Richet, C.: The physiological action of rubidium salts. Arch. Physiol. et Path. 3, 101–151 (1886).Google Scholar
  12. 12.
    Rottenbiller, J.: The curative effects of rubidium-ammonium-bromide. Gyógyaszat 43, 505–507 (1889) (Hungarian).Google Scholar
  13. 13.
    Stolk, J. M., Nowack, W. J., Barchas, J. D., Platman, S. R.: Brain norepinephrine: Enhanced turnover after rubidium treatment. Science 168, 501–503 (1970).Google Scholar
  14. 14.
    Urbahn, K.: Über Rubidiumiodide. Dissertation, Kiel 1895.Google Scholar
  15. 15.
    Vina, J., Bellido, J., Moratom F.: Experimental electrocardiographic studies in the dog on the influence of alkali ions Li+, Na+, K+, Rb+ and Cs+. Z. Biol. 115, 185–193 (1966).Google Scholar
  16. 16.
    Yamagata, N.: The concentration of common cesium and rubidium in human body. J. Radiat. Res. (Tokyo) 3, 9–30 (1962).Google Scholar
  17. 17.
    —, Iwashima, K., Nagai, T., Watari, K., Iinuma, T. A.: In vivo experiment on the metabolism of caesium in human blood with reference to rubidium and potassium. J. Radiat. Res. (Tokyo) 7, 29–44 (1966).Google Scholar
  18. 18.
    Zipser, A., Pinto, H. B., Freedman, A. S.: Distribution and turnover of administered rubidium (Rb86) carbonate in blood and urine of man. J. appl. Physiol. 5, 317–322 (1953).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Ronald R. Fieve
    • 1
  • Herbert L. Meltzer
    • 1
  • Reginald M. Taylor
    • 1
  1. 1.N.Y. State Psychiatric InstituteUSA

Personalised recommendations