, Volume 18, Issue 4, pp 412–420 | Cite as

Investigation into the possible influence of chlorinated amphetamine derivatives on 5-hydroxytryptamine synthesis in man

  • H. M. van Praag
  • J. Korf
  • F. van Woudenberg
Human Pharmacology


In test animals, 4-chloro-N-methylamphetamine (CMA) and 4-chloro-amphetamine (4-CA) cause a decrease in the cerebral 5-HT and 5-HIAA concentrations; they exert no appreciable influence on catecholamine concentrations. In man, these compounds have a therapeutic effect on depression. In terms of antidepressant effect, they resemble not so much the nonchlorinated amphetamine derivatives as the true antidepressants.

This paper considers the question whether the influence of CMA and 4-CA on the 5-HT metabolism is based on inhibition of 5-HT synthesis. No arguments to support this hypothesis were found; findings obtained did support the postulate that these compounds are 5-HT depletors.

In conclusion, a possible explanation of the antidepressant effect of chlorinated amphetamine derivatives is offered.


Serotonin 4-Chlorinated Amphetamines Antidepressants Depression Central Stimulants 


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • H. M. van Praag
    • 1
  • J. Korf
    • 1
  • F. van Woudenberg
    • 1
  1. 1.Department of Biological Psychiatry and Central Isotope LaboratoryState UniversityGroningenThe Netherlands

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