, Volume 19, Issue 2, pp 114–127 | Cite as

L-Tryptophane and sleep

  • Ernest Hartmann
  • Richard Chung
  • Ching-Piao Chien
Human Pharmacology


L-Tryptophane, an essential amino acid and a precursor of serotonin, is shown to have definite effects on human sleep. In normal subjects it reduces sleep latency and slightly increases sleep length without altering the qualitative characteristics of polygraphically recorded sleep. In a double-blind study of 24 hospitalized insomniac patients, doses of 4 g or 5 g of L-tryptophane significantly increased sleep time, reduced sleep latency, and reduced the number of awakenings.

Key -Words

Sleep Tryptophane Serotonin Insomnia Hypnogenic Medication 


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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Ernest Hartmann
    • 1
  • Richard Chung
    • 1
  • Ching-Piao Chien
    • 1
  1. 1.Department of PsychiatryTufts University School of Medicine Boston State HospitalUSA

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