, Volume 35, Issue 2, pp 173–177

Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study

  • D. Simon
  • P. Preziosi
  • E. Barrett-Connor
  • M. Roger
  • M. Saint-Paul
  • K. Nahoul
  • L. Papoz


Plasma insulin is a risk factor for diabetes mellitus and cardiovascular disease in men. We investigated the association between plasma testosterone and plasma insulin in an occupational sample of 1292 healthy adult men. Total plasma testosterone decreased with each decade of age and insulin increased with each decade of age. In these cross-sectional data, this significant graded inverse association between testosterone and insulin was independent of age. The association was reduced but not explained by the addition of obesity and subscapular skinfold to the model. Adjustment for alcohol consumption, cigarette smoking and plasma glucose did not materially alter the association. These results are the reverse of the positive association of androgens with insulin in women and suggest alternative possible explanations for the effect of hyperinsulinaemia on cardiovascular disease risk. Prospective studies will be necessary to determine the direction and causal nature of this association.

Key words

Insulin insulin resistance testosterone androgens healthy men cardiovascular risk factors 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • D. Simon
    • 1
    • 2
  • P. Preziosi
    • 1
  • E. Barrett-Connor
    • 5
  • M. Roger
    • 3
  • M. Saint-Paul
    • 4
  • K. Nahoul
    • 3
  • L. Papoz
    • 1
  1. 1.INSERM Unité 21Villejuif
  2. 2.Service de Diabétologie et Département de Santé PubliqueHôpital Henri MondorCréteil
  3. 3.Fondation de Recherche en HormonologieFresnes
  4. 4.Laboratoires de la DASESParisFrance
  5. 5.Department of Community and Family MedicineUniversity of CaliforniaSan DiegoUSA

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