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Role of central dopaminergic receptors in manic response of cats to morphine

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The administration of morphine in conscious cats produces a manic response characterized by hyperexcitement and aggressive behaviour. This manic response was prevented by pretreatment of cats with either CNS catecholamine depletors (reserpine and tetrabenazine) or central dopaminergic receptor blocking agents eg. haloperidol and chlorpromazine. On the other hand, alpha and beta adrenergic receptor blocking agents-phenoxybenzamine and propranolol did not antagonise the morphine-mania. Similarly, anticholinergic (atropine), antihistaminic (mepyramine) and antiserotonin (LSD-25) agents did not prevent morphinemania. It is concluded that morphine releases dopamine in the CNS which in turn excites the central dopaminergic receptors to induce the manic response.

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Dhasmana, K.M., Dixit, K.S., Jaju, B.P. et al. Role of central dopaminergic receptors in manic response of cats to morphine. Psychopharmacologia 24, 380–383 (1972). https://doi.org/10.1007/BF00402532

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Key words

  • Morphine Mania
  • Central Dopaminergic Receptors
  • Catecholamine Depletors
  • Autonomic Blocking Agents