, Volume 12, Issue 2, pp 158–163

Self-administration of d-amphetamine by rats

  • Roy Pickens
  • Wayne C. Harris
Short Communications

DOI: 10.1007/BF00401545

Cite this article as:
Pickens, R. & Harris, W.C. Psychopharmacologia (1968) 12: 158. doi:10.1007/BF00401545


Self-administration of d-amphetamine by rats was characterized by periods of drug intake and abstinence. Frequency of responding for drug injection was found to vary inversely as a function of drug dose per infusion (magnitude of reinforcement), and directly as a function of number of responses required per infusion (fixed-ratio reinforcement schedule). In several regards, reinforcement by d-amphetamine resembled that produced by electrical stimulation of the brain.

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • Roy Pickens
    • 1
  • Wayne C. Harris
  1. 1.Department of Pharmacology, Psychiatry and NeurologyUniversity of Minnesota Medical SchoolMinneapolisUSA

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