Self-administration of d-amphetamine by rats
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- Pickens, R. & Harris, W.C. Psychopharmacologia (1968) 12: 158. doi:10.1007/BF00401545
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Self-administration of d-amphetamine by rats was characterized by periods of drug intake and abstinence. Frequency of responding for drug injection was found to vary inversely as a function of drug dose per infusion (magnitude of reinforcement), and directly as a function of number of responses required per infusion (fixed-ratio reinforcement schedule). In several regards, reinforcement by d-amphetamine resembled that produced by electrical stimulation of the brain.