Spontaneous locomotor activity, rotarod performance and shuttlebox avoidance behavior were measured in rats 24 hours after each of ten daily injections of reserpine. Locomotor activity was significantly depressed after the third and fourth daily injections. However, by the end of the treatment period, locomotor activity of reserpnized rats was significantly higher than that of saline-injected controls. Rotarod performance and shuttle-box avoidance behavior were significantly depressed following the third and fourth doses, respectively, and showed no recovery during the total period of treatment. Body weights dropped progressively after the third day but never fell below 74% of control. Possible explanations for the differential behavioral effects are discussed.
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Brodie, B. B., M. S. Comer, E. Costa, and A. Dlabac: The role of brain serotonin in the mechanism of the central action of reserpine. J. Pharmacol. exp. Ther. 152, 340–349 (1966).
Dahlström, A., K. Fuxe, and N.-Å. Hillarp: Site of action of reserpine. Acta pharmacol. (Kbh.) 22, 277–292 (1965).
Fuxe, K.: The distribution of monoamine nerve terminals in the central nervous system. Acta physiol. scand. 64 (suppl. 247) (1965).
Glowinski, J., J. Axelrod, and L. L. Iversen: Regional studies of catecholamines in the rat brain IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine. J. Pharmacol. exp. Ther. 153, 30–41 (1966).
Häggendal, J., and M. Lindqvist: Brain monoamine levels and behavior during long-term administration of reserpine. Int. J. Neuropharmacol. 3, 59–64 (1964).
Hillarp, N.-Å., K. Fuxe, and A. Dahlström: Demonstration and mapping of central neurons containing dopamine, noradrenaline, and 5-hydroxytryptamine and their reactions to psychopharmaca. Pharmacol. Rev. 18, 727–741 (1966).
Pirch, J. H., R. H. Rech, and K. E. Moore: Depression and recovery of the electrocorticogram, behavior, and brain amines in rats treated with reserpine. Int. J. Neuropharmacol: In press (1967).
Rech, R. H.: Antagonism of reserpine behavioral depression by d-amphetamine. J. Pharmacol. exp. Ther. 146, 369–376 (1964).
—, and K. E. Moore: Alterations in behavior and brain catecholamine levels in rats treated with alpha-methyltyrosine. J. Pharmacol. exp. Ther. 153, 412–419 (1966).
Spector, S., A. Sjoerdsma, and S. Udenfriend: Blockade of endogenous norepinephrine synthesis by alpha-methyl-tyrosine, and inhibitor of tyrosine hydroxylase. J. Pharmacol. exp. Ther. 147, 86–95 (1965).
Wada, J. A., and E. G. McGeer: Central aromatic amines and behavior III. Correlative analysis of conditioned approach behavior and brain amine levels of serotonin and catecholamines in monkeys. Arch. Neurol. (Chic.) 14, 129–142 (1966).
Supported by USPHS grants NB 06013 and MH 11469.
Postdoctoral fellow of the National Institute of General Medical Sciences (1-F2-GM31, 546-01).
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Pirch, J.H., Rech, R.H. Behavioral recovery in rats during chronic reserpine treatment. Psychopharmacologia 12, 115–122 (1968). https://doi.org/10.1007/BF00401540
- Body Weight
- Treatment Period
- Locomotor Activity
- Behavioral Effect