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Psychopharmacologia

, Volume 12, Issue 4, pp 358–366 | Cite as

Comparative behavioral effects of several anticholinergic agents in rats

  • S. N. Pradhan
  • Thomas Roth
Short Communications

Summary

The behavioral effects of JB 329 (Ditran) were compared with those of several anticholinergic agents in rats.

The tertiary nitrogen-containing compounds (i.e. JB 329, JB 336, atropine, scopolamine) caused an increase in their spontaneous motor activity, decrease in food and water intake and an over-all decrease in the response in the various phases of the multiple schedules of reinforcement (i.e. shock avoidance, fixed-ratio water reinforcement, and time-out). The potency of JB 329 was similar to that of scopolamine and greater than that of JB 336. Atropine was 10 or more times less potent than scopolamine.

The quaternary analogues of these drugs showed similar, though very slight, and sometimes reverse effects. The site of action of the tertiary compounds thus appears to be central.

Keywords

Water Intake Reverse Effect Motor Activity Atropine Behavioral Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abood, L. G., A. M. Ostfeld, and J. H. Biel: Structure-activity relationship of 3-piperidyl benzilates with psychotogenic properties. Arch. int. Pharmacodyn. 120, 186–200 (1959).PubMedGoogle Scholar
  2. Bell, C., S. Gershon, B. Carroll, and G. Holan: Behavioral antagonism to a new psychotomimetic: JB-329. Arch. int. Pharmacodyn. 147, 9–25 (1964).PubMedGoogle Scholar
  3. Bercel, N. A.: Clinical experience with a new type of antidepressant drug; Ditran. J. Neuropsychiat. 2, 271–278 (1961).Google Scholar
  4. Biel, J. H., L. G. Abood, W. K. Hoya, H. A. Leiser, P. A. Nuhfer, and E. F. Kluchesky: Central stimulants. II. Cholinergic blocking agents. J. Org. Chem. 26, 4096–4103 (1961).Google Scholar
  5. —, P. A. Nuhfer, W. K. Hoya, H. A. Leiser, and L. G. Abood: Cholinergic blockade as an approach to the development of new psychotropic agents. Ann. N.Y. Acad. Sci. 96, 251–262 (1962).PubMedGoogle Scholar
  6. —, E. P. Sprengeler, H. A. Leiser, J. Horner, A. Drukker, and H. L. Friedman: Antispasmodics. II. Derivatives of N-substituted-3-piperidols. J. Amer. chem. Soc. 77, 2250–2256 (1955).Google Scholar
  7. Carlton, P. L.: Cholinergic mechanism in the control of behavior by the brain. Psychol. Rev. 70, 19–39 (1963).PubMedGoogle Scholar
  8. DeVito, R. A., and I. M. Frank: Ditran: Searchlights on psychosis. J. Neuropsychiat. 5, 300–305 (1964).Google Scholar
  9. Ferster, C. B., and B. F. Skinner: Schedules of reinforcement. New York: Appleton Century-Crofts 1957.Google Scholar
  10. Goodman, L. S., and A. Gilman: The pharmacological basis of therapeutics, 3rd edition, p. 525. New York: The Macmillan Co. 1965.Google Scholar
  11. Longo, V. G.: Behavioral and electroencephalographic effects of atropine and related compounds. Pharmacol. Rev. 18, 965–996 (1966).PubMedGoogle Scholar
  12. Meduna, L. J., and L. G. Abood: Studies of a new drug (Ditran) in depression states. J. Neuropsychiat. 1, 20–22 (1959).Google Scholar
  13. Meyers, B., K. H. Roberts, R. H. Riciputi, and E. F. Domino: Some effects of muscarinic cholinergic blocking drugs on behavior and the electrocorticogram. Psychopharmacologia (Berl.) 5, 289–300 (1964).Google Scholar
  14. Parkes, M. W.: An examination of central action characteristic of scopolamine: Comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters. Psychopharmacologia (Berl.) 7, 1–19 (1965).Google Scholar
  15. Pradhan, S. N., B. Beer, T. Roth, and S. N. Dutta: Some behavioral effects of Ditran (JB 329) in rats. Arch. int. Pharmacodyn. 170, 264–275 (1967a).PubMedGoogle Scholar
  16. —, T. Roth, and B. Beer: The effects of several anticholinergic agents on a multiple schedule of reinforcement in rats. Proc. 5th International Congress of Neuropsychopharmacology, pp. 1037–1041. Amsterdam: Excerpta Medica Foundation (1967b).Google Scholar
  17. Salmoiraghi, G. C., E. Costa, and F. E. Bloom: Pharmacology of central synapses. Ann. Rev. Pharmacol. 5, 213–234 (1965).Google Scholar
  18. Sidman, M.: Avoidance conditioning with brief shock and no exteroceptive warning signal. Science 118, 157–158 (1953).PubMedGoogle Scholar
  19. Stein, L.: Anticholinergic drugs and the control of thirst. Science 139, 46–48 (1963).PubMedGoogle Scholar
  20. Votava, Z.: Pharmacology of central cholinergic synapses. Ann. Rev. Pharmacol. 7, 223–236 (1967).PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • S. N. Pradhan
    • 1
  • Thomas Roth
    • 1
  1. 1.Department of PharmacologyHoward University, College of MedicineWashington, D. C.

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