Comparative behavioral effects of several anticholinergic agents in rats
- 43 Downloads
The behavioral effects of JB 329 (Ditran) were compared with those of several anticholinergic agents in rats.
The tertiary nitrogen-containing compounds (i.e. JB 329, JB 336, atropine, scopolamine) caused an increase in their spontaneous motor activity, decrease in food and water intake and an over-all decrease in the response in the various phases of the multiple schedules of reinforcement (i.e. shock avoidance, fixed-ratio water reinforcement, and time-out). The potency of JB 329 was similar to that of scopolamine and greater than that of JB 336. Atropine was 10 or more times less potent than scopolamine.
The quaternary analogues of these drugs showed similar, though very slight, and sometimes reverse effects. The site of action of the tertiary compounds thus appears to be central.
KeywordsWater Intake Reverse Effect Motor Activity Atropine Behavioral Effect
Unable to display preview. Download preview PDF.
- Bercel, N. A.: Clinical experience with a new type of antidepressant drug; Ditran. J. Neuropsychiat. 2, 271–278 (1961).Google Scholar
- Biel, J. H., L. G. Abood, W. K. Hoya, H. A. Leiser, P. A. Nuhfer, and E. F. Kluchesky: Central stimulants. II. Cholinergic blocking agents. J. Org. Chem. 26, 4096–4103 (1961).Google Scholar
- —, E. P. Sprengeler, H. A. Leiser, J. Horner, A. Drukker, and H. L. Friedman: Antispasmodics. II. Derivatives of N-substituted-3-piperidols. J. Amer. chem. Soc. 77, 2250–2256 (1955).Google Scholar
- DeVito, R. A., and I. M. Frank: Ditran: Searchlights on psychosis. J. Neuropsychiat. 5, 300–305 (1964).Google Scholar
- Ferster, C. B., and B. F. Skinner: Schedules of reinforcement. New York: Appleton Century-Crofts 1957.Google Scholar
- Goodman, L. S., and A. Gilman: The pharmacological basis of therapeutics, 3rd edition, p. 525. New York: The Macmillan Co. 1965.Google Scholar
- Meduna, L. J., and L. G. Abood: Studies of a new drug (Ditran) in depression states. J. Neuropsychiat. 1, 20–22 (1959).Google Scholar
- Meyers, B., K. H. Roberts, R. H. Riciputi, and E. F. Domino: Some effects of muscarinic cholinergic blocking drugs on behavior and the electrocorticogram. Psychopharmacologia (Berl.) 5, 289–300 (1964).Google Scholar
- Parkes, M. W.: An examination of central action characteristic of scopolamine: Comparison of central and peripheral activity in scopolamine, atropine and some synthetic basic esters. Psychopharmacologia (Berl.) 7, 1–19 (1965).Google Scholar
- —, T. Roth, and B. Beer: The effects of several anticholinergic agents on a multiple schedule of reinforcement in rats. Proc. 5th International Congress of Neuropsychopharmacology, pp. 1037–1041. Amsterdam: Excerpta Medica Foundation (1967b).Google Scholar
- Salmoiraghi, G. C., E. Costa, and F. E. Bloom: Pharmacology of central synapses. Ann. Rev. Pharmacol. 5, 213–234 (1965).Google Scholar