Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse
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A systematic observational method is described for comprehensively assessing and quantifying the behavioral and physiologic state of the mouse and its response to drugs. With this method, the pattern profile of various classes of pharmacologic agents and their members can be identified and differentiated, and the relative specificity of their actions defined. The method is applicable to a wide range of investigative goals. Inter- and intra-observer reliability studies have shown it to meet the pragmatic requirements for research.
Key-WordsMouse Animal Behavior Observational Measurement Drugs Biological Assay
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- Bernard, C.: An introduction to the study of experimental medicine, pp. 89. U.S.A.: Henry Schuman Inc. 1949.Google Scholar
- Geller, I., and J. Seifter: The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in rats. Pharmacologie 1, 482–492 (1960).Google Scholar
- Irwin, S.: Drug screening and evaluative procedures. Science 136, 123–128 (1962).Google Scholar
- —: Drug screening and evaluation of new compounds in animals. In: H. Nodine and P. E. Siegler, Eds.: Animal and clinical pharmacologic techniques in drug evaluation. Philadelphia: Year Book Med. Pubs. 1964.Google Scholar
- —: Considerations for the pre-clinical evaluation of new psychiatric drugs: A case study with phenothiazine-like tranquilizers. Psychopharmacologia (Berl.) 9, 259–287 (1966).Google Scholar
- - System analysis: A strategy for drug experimentation and evaluation. Perspectives in Biology and Medicine, 1968 (in press).Google Scholar
- —, S. Slabok, P. L. DeBiase, and W. M. Govier: Perphenazine (Trilafon), a new potent tranquilizer and antiemetic: I. Behavior profile, acute toxicity and behavioral mode of action. Arch. int. Pharmacodyn. 118, 358–374 (1959).Google Scholar