Immunogenetics

, Volume 18, Issue 1, pp 79–89 | Cite as

Structural analysis of insulin determinants seen by T cells directed by H-2 genes

  • Janet Talmon
  • Graziella Ranghino
  • Ada Yonath
  • Irun R. Cohen
Article

Abstract

The magnitude of the immune response of lymphocytes to defined antigenic determinants of ungulate insulins is controlled by the products of H-2 genes. Based on the crystallographically solved structure of porcine insulin, the close homology of all the ungulate insulins, and the amino acid substitutions, we built models of the different insulins. We analyzed the likely conformations of the antigenic determinants, and proposed structural specificities accounting for the immunologic phenomena observed.

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Janet Talmon
    • 1
  • Graziella Ranghino
    • 2
  • Ada Yonath
    • 2
  • Irun R. Cohen
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Department of Structural ChemistryThe Weizmann Institute of ScienceRehovotIsrael

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