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H-2-restricted graft-versus-host reaction: Foreign determinants and restriction elements

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Nylon-wool-purified T cells from radiation chimeras cause a lethal graft-versus-host reaction (GVHR) in irradiated, bone-marrow-protected recipients only if the recipient shares a restriction element with the T-cell donor and also expresses antigens foreign to the donor. Class I molecules (H-2K and H-2D) can act as restriction elements, but restriction to class II molecules could not be demonstrated. However, class II molecules as well as H-2K and some non-H-2 determinants could serve as foreign antigens.

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Kindred, B. H-2-restricted graft-versus-host reaction: Foreign determinants and restriction elements. Immunogenetics 18, 57–63 (1983). https://doi.org/10.1007/BF00401356

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  • Foreign Antigen
  • Restriction Element
  • Foreign Determinant
  • Radiation Chimera
  • Recipient Share