Nylon-wool-purified T cells from radiation chimeras cause a lethal graft-versus-host reaction (GVHR) in irradiated, bone-marrow-protected recipients only if the recipient shares a restriction element with the T-cell donor and also expresses antigens foreign to the donor. Class I molecules (H-2K and H-2D) can act as restriction elements, but restriction to class II molecules could not be demonstrated. However, class II molecules as well as H-2K and some non-H-2 determinants could serve as foreign antigens.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Cudkowicz, G.: Genetic control of resistance to allogeneic and xenogeneic bone-marrow grafts in mice. Transplant. Proc. 7: 155–159, 1975a
Cudkowicz, G.: Rejection of bone marrow allografts by irradiated athymic mice. Proc. Am. Assoc. Cancer Res. 16: 170, 1975b
Elkins, W. L.: Cellular immunology and the pathogenesis of graft versus host reactions. Progr. Allergy 15: 78–187, 1971
Elkins, W. L. and Quant, M. M.: Regulatory effect of H-2D region antigens in the graft-vs-host response: F1 hybrid resistance to alloreactive T cells. J. Immunol. 127: 1459–1462, 1981
Grebe, S. C. and Streilein, J. W.: Graft-versus-host reactions: A review. Adv. Immunol. 22: 119–221, 1976
Julius, M. W., Simpson, E., and Herzenberg, L. A.: A rapid method for the isolation of thymus derived murin lymphocytes. Eur. J. Immunol. 3: 645–649, 1973
Kindred, B.: H-2-restricted lethal graft-versus-host disease. Immunogenetics 14: 527–533, 1981
Kindred, B.: H-2-restricted GVH reaction caused by T cells from normal donors of certain strains. Immunogenetics 17: 203–209, 1983
Klein, J.: The histocompatibility-2 (H-2) complex. In The Mouse in Biomedical Research, Vol. l, pp. 119–158, Academic Press Inc. 1981
Korngold, R. and Sprent, J.: H-2 restriction of T cells causing lethal graft-versus-host disease across minor histocompatibility barriers in mice. Transplant. Proc. 13: 1217–1219, 1981
Korngold, R. and Sprent, J.: Features of T cells causing H-2-restricted lethal graft-vs-host disease across minor histocompatibility barriers. J. Exp. Med. 155: 872–883, 1982
Nakano, K., Nakamura, I., and Cudkowicz, G.: F1 hybrid-anti-parental H-2b cell mediated lympholysis: Genetic control of target antigens by the H-2D region. J. Immunol. 127: 173–178, 1981
Shearer, G. M. and Polisson, R. P.: Mutual recognition of parental and F1 lymphocytes. J. Exp. Med. 151: 20–31, 1980
Zinkernagel, R. M. and Doherty, P. C.: MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function and responsiveness. Adv. Immunol. 27: 51, 1979
About this article
Cite this article
Kindred, B. H-2-restricted graft-versus-host reaction: Foreign determinants and restriction elements. Immunogenetics 18, 57–63 (1983). https://doi.org/10.1007/BF00401356
- Foreign Antigen
- Restriction Element
- Foreign Determinant
- Radiation Chimera
- Recipient Share