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Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis

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Rhesus monkeys, conditioned to respond to a scaled series of different sized letters E by a shock-reinforced psychophysical method of constant stimuli, were tested following treatment with several drugs. The primary measure employed was change in reaction time — a variable which proved sensitive to magnitude and overall direction of change. These data were plotted as a function of stimulus values for each dose of drug. The resulting curves were analyzed to determine significant relationships between various classes of drugs.

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This work was done under Contract No. DA18-108-AMC-108(A) from the U. S. Army Research Laboratories, Edgewood Arsenal, Edgewood, Maryland to FMC Corporation, Princeton, New Jersey with Abbott Laboratories as subcontractor.

In conducting the research reported herein, the investigators adhered to “Principles of Laboratory Animal Care” as established by the National Society for Medical Research and to the “Guiding Principles for the Humane Care and Use of Animals, December 15, 1962” as stated by the American Psychological Association.

The authors are grateful to C. R. Schuster, Department of Pharmacology, University of Michigan for opinion concerning the experimental design; P. G. Sanders, Applied Mathematics Section, Abbott Laboratories, for statistical assistance and to F. A. Gustafson for technical assistance.

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Brown, H., Bass, W.C. Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis. Psychopharmacologia 11, 143–153 (1967). https://doi.org/10.1007/BF00401251

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  • Reaction Time
  • Significant Relationship
  • Rhesus Monkey
  • Avoidance Behavior
  • Primary Measure