Reserpine given after nialamide or parygline is 15–20 times more toxic in aggregated than in isolated mice.
Hyperthermia and hypermotility produced by reserpine after MAO inhibitor pretreatment are considerably greater in aggregated than in isolated mice.
The increasee toxicity is related to the change of brain monamine level, because it is diminished by α-methyl-m-tyrosine and prenylamine; quantitative relationship could not be established.
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Pfeifer, A.K., Galambos, É. Toxicity and the action of reserpine on brain monoamines after pretreatment with monoamine oxidase inhibitors in isolated and aggregated mice. Psychopharmacologia 11, 130–135 (1967). https://doi.org/10.1007/BF00401249
- Monoamine Oxidase
- Oxidase Inhibitor