Assignment of human uroporphyrinogen decarboxylase (URO-D) to the p34 band of chromosome 1
- 40 Downloads
A cDNA probe corresponding to mRNA encoding human uroporphyrinogen decarboxylase (URO-D) was used to determine the chromosomal localization of the URO-D gene in the human genome. In agreement with previous studies, we have found that the locus for URO-D is located on chromosome 1 in hybrid cell mapping panels. The use of in sity hybridization allowed us to map the URO-D locus to band 1p34.
KeywordsInternal Medicine Metabolic Disease Human Genome Cell Mapping Chromosomal Localization
Unable to display preview. Download preview PDF.
- Carritt B (1985) Genomic cloning of the short arm of human chromosome 1. Cytogenet Cell Genet 40:599Google Scholar
- Eiberg H, Mohrt J, Staub-Nielsen L (1983) δ-Aminolevulinate dehydrase: syntheny with ABO-AK1-ORM (and assignment to chromosome 9). Clin Genet 23:151–154Google Scholar
- Grandchamp B, Weil D, Nordman Y, N'Guyen VC, de Verneuil H, Foubert C, Gross MS (1983) Assignment of the human coproporphyrinogen oxidase to chromosome 9. J Hum Genet 64:180–183Google Scholar
- Romeo PH, Raich N, Dubart A, Beaupain D, Cohen-Solal M, Goossens M (1986) Molecular cloning and nucleotide sequence of a complete human uroporphyrinogen decarboxylase cDNA. J Biol Chem (in press)Google Scholar