Human Genetics

, Volume 73, Issue 3, pp 225–229 | Cite as

Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism

  • Nancy E. Cooke
  • H. F. Willard
  • E. V. David
  • Donna L. George
Original Investigations


Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4. In situ hybridization of 3H-labeled DBP cDNA to human metaphase chromosomes confirmed this assignment and allowed regional localization to bands 4q11–4q13. A restriction fragment length polymorphism associated with the DBP gene that should prove useful in future linkage studies was identified with the enzyme BamHI.


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Nancy E. Cooke
    • 1
    • 2
  • H. F. Willard
    • 4
  • E. V. David
    • 1
    • 2
  • Donna L. George
    • 2
    • 3
  1. 1.Department of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Human GeneticsUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Howard Hughes Medical InstituteUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.Department of Medical GeneticsUniversity of TorontoOntarioCanada

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