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Diabetologia

, Volume 36, Issue 8, pp 767–770 | Cite as

Intracellular and extracellular magnesium depletion in Type 2 (non-insulin-dependent) diabetes mellitus

  • L. M. Resnick
  • B. T. Altura
  • R. K. Gupta
  • J. H. Laragh
  • M. H. Alderman
  • B. M. Altura
Originals

Summary

To investigate alterations of magnesium metabolism in Type 2 (non-insulin-dependent) diabetes mellitus, we utilized a new magnesium-specific selective ion electrode apparatus to measure serum ionized magnesium (Mg-io) in fasting subjects with and without Type 2 diabetes, and compared these values to levels of serum total magnesium, and of intracellular free magnesium (Mgi) analysed by 31P-NMR spectroscopy. Both Mg-io (0.630±0.008 vs 0.552± 0.008 mmol/l, p<0.001) and Mgi (223.3±8.3 vs 184± 13.7 mmol/l,p<0.001), but not serum total magnesium, were significantly reduced in Type 2 diabetes compared with nondiabetic control subjects. Furthermore, a close relationship was observed between serum Mg-io and Mgi (r=0.728, p<0.001). We suggest that magnesium deficiency, both extracellular and intracellular, is a characteristic of chronic stable mild Type 2 diabetes, and as such, may predispose to the excess cardiovascular morbidity of the diabetic state. Furthermore, by more adequately reflecting cellular magnesium metabolism than total serum magnesium levels, Mg-io measurements may provide a more readily available tool than has heretofore been available to analyse magnesium metabolism in a variety of diseases.

Key words

Magnesium nuclear magnetic resonance spectroscopy Type 2 (non-insulin-dependent) diabetes mellitus erythrocytes ion selective electrode 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • L. M. Resnick
    • 1
    • 4
  • B. T. Altura
    • 2
  • R. K. Gupta
    • 3
  • J. H. Laragh
    • 1
  • M. H. Alderman
    • 3
  • B. M. Altura
    • 2
  1. 1.Cardiovascular CenterNew York Hospital-Cornell Medical CenterNew YorkUSA
  2. 2.Department of PhysiologyState University of New YorkBrooklynUSA
  3. 3.Departments of Epidemiology, Physiology and BiophysicsAlbert Einstein College of MedicineBronxUSA
  4. 4.Division of Endocrinology and HypertensionWayne State University Medical Center University Health Center-4HDetroitUSA

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