Journal of Cancer Research and Clinical Oncology

, Volume 95, Issue 2, pp 187–196 | Cite as

Spontaneous endocrine tumors in Sprague-Dawley rats

  • H. Suzuki
  • U. Mohr
  • G. Kimmerle
Original Papers Clinical Oncology or Epidemiology


Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

Key words

Spontaneous endocrine tumors Sprague-Dawley rats Multiple endocrine tumors 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Andersson, P.: High incidence of chromophobe pituitary adenoma-like lesions in an inbred-Sprague-Dawley breeding rat colony. Acta Vet. Scand. 10, 111–117 (1969)PubMedGoogle Scholar
  2. Ballards, H.S., Frame, B., Hartsock, R.J.: Familial multiple endocrine adenoma-peptic ulcer complex. Medicine 43, 481–516 (1964)PubMedGoogle Scholar
  3. Boorman, G.A., van Noord, M.J., Hollander, C.F.: Naturally occurring medullary thyroid carcinoma in the rat. Arch. Path. 94, 35–41 (1972)PubMedGoogle Scholar
  4. Carney, J., Aidam, C.J., Sizemore, G.W., Sheps, S.G.: Adrenal Medullary disease in multiple endocrine neoplasia, type 2, pheochromocytoma and its precursors. Am. J. Clin. Pathol. 66, 279–290 (1976)PubMedGoogle Scholar
  5. Catalona, W.J., Engelman, K., Ketcham, A.S., Hammond, W.G.: Familial medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenoma (Sipple's syndrom). Cancer 28, 1245–1254 (1971)PubMedGoogle Scholar
  6. Crain, R.C.: Spontaneous tumors in the Rochester strain of the Wistar rat. Am. J. Pathol. 34, 311–355 (1958)PubMedGoogle Scholar
  7. Curtis, M.R., Bullock, F.D., Dunning, W.F.: Statistical study of the occurrence of spontaneous tumors in a large colony of rats. Am. J. Cancer 15, 67–121 (1931)Google Scholar
  8. DeLellis, R.A., Balogh, K.: Histochemical characteristics of parafollicular cells and medullary thyroid carcinoma. Am. J. Pathol. 72, 119–128 (1973)PubMedGoogle Scholar
  9. Ezrin, C., Murray, S.: The cells of the human adenohypophysis in pregnancy, thyroid and adrenal cortical disorders. In: Cytology de l'adenohypophyse, Benoit, J., DaLage, C. (eds.), pp. 183–199. Paris: CNRS 1963Google Scholar
  10. Fleischmann, W.: Spontaneous endocrine diseases in laboratory animals. In the pathology of laboratory animals. Ribelin, W.E., McCoy, J.R. (eds.), pp. 60–92. Springfield (Illinois): Thomas, C.C. 1951Google Scholar
  11. Furth, J., Nakane, P.K., Pasteels, J.L.: Tumors of the pituitary gland. In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 2), Turusov, V.S. (ed.), pp. 201–237. Lyon: International Agency for Research on Cancer, 1976Google Scholar
  12. Gillman, J., Gilbelt, C., Spence, I.: Pheochromocytoma in the rat; pathogenesis and collateral reactions and its relation to comparable tumors in man. Cancer 6, 494–511 (1953)PubMedGoogle Scholar
  13. Gomori, G.: Aldehyde fuchsin: a new stain for elastic tissue. Am. J. Clin. Pathol. 20, 665–666 (1950)PubMedGoogle Scholar
  14. Grimelius, L.: A silver nitrate stain for α2 cell in human pancreatic islets. Acta Soc. Med. Upsal. 73, 243–270 (1968)PubMedGoogle Scholar
  15. Hollander, C.F., Snell, K.C.: Tumors of the adrenal gland. In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 2), Turusov, V.S. (ed.), pp. 239–271. Lyon: International Agency for Research on Cancer 1976Google Scholar
  16. Ito, A., Moy, P., Kortwright, K., Clarke, S., Furth, J., Meites, J.: Incidence and character of the spontaneous pituitary tumors in strain CR and W/Fu male rats. J. Natl. Cancer Inst. 49, 701–711 (1972)PubMedGoogle Scholar
  17. Jacob, B.B., Huseby, R.A.: Neoplasms occurring in aged Fisher rats with special reference to testicular, uterine, and thyroid tumors. J. Natl. Cancer Inst. 39, 303–309 (1967)Google Scholar
  18. Lindsay, S., Nichols, C.W. Jr., Chaikoff, I.L.: Naturally occurring thyroid carcinoma in the rat: Similarities to human medullary carcinoma. Arch. Path. 86, 353–364 (1968)Google Scholar
  19. Ljungberg, O., Cederquist, E., Standnitz, W.: Medullary thyroid carcinoma and pheochromocytoma: A familial chromaffinomatosis. Br. Med. J. 1, 279–281 (1967)PubMedGoogle Scholar
  20. Maekawa, A., Odashima, S.: Spontaneous tumors in ACI/N rats. J. Natl. Cancer. Inst. 55, 1437–1445 (1975)PubMedGoogle Scholar
  21. Napalkov, N.P.: Tumors of the thyroid gland: In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 2), Turusov, V.S. (ed.), pp. 239–271, Lyon: International Agency for Research on Cancer 1976Google Scholar
  22. Prejean, J.D., Peckham, J.C., Casey, D.P., Weisburger, E.K., Weisburger, I.H.: Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res, 33, 2768–2773 (1973)PubMedGoogle Scholar
  23. Roe, F.J.C., Roberts, J.D.B.: Tumors of the pancreas. In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 1), Turusov, V.S. (ed.), pp. 141–150. Lyon: International Agency for Research on Cancer 1973Google Scholar
  24. Rosen, V.J., Castanera, T.J., Kimeldorf, D.J., Jones, D.C.: Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. Lab. Invest. 11, 204–210 (1962)PubMedGoogle Scholar
  25. Rowlatt, U.: Spontaneous epithelial tumors of the pancreas of mammals. Br. J. Cancer 21, 82–107 (1967)PubMedGoogle Scholar
  26. Saxton, J.A. Jr., Graham, J.B.: Chromophobic adenoma-like lesions of the rats hypophysis. Cancer Res. 4, 168–178 (1944)Google Scholar
  27. Sipple, J.H.: Association of pheochromocytoma with carcinoma of thyroid gland. Am. J. Med. 31, 163–166 (1961)CrossRefGoogle Scholar
  28. Thompson, S.W., Huseby, R.A., Fox, M.R., Davis, C.L., Hunt, R.D.: Spontaneous tumors in the Sprague-Dawley rat. J. Natl. Cancer Inst. 27, 1037–1057 (1961)PubMedGoogle Scholar
  29. Thompson, S.W., Hunt, R.D.: Spontaneous tumors in the Sprague-Dawley rat: Incidence rates of some type of neoplasms as determined by serial section versus single section technics. Ann. NY Acad. Sci. 108, 832–845 (1963)Google Scholar
  30. Wermer, P.: Genetic aspects of adenomatosis of endocrine gland. Am. J. Med. 16, 363–371 (1954)CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • H. Suzuki
    • 1
  • U. Mohr
    • 1
  • G. Kimmerle
    • 2
  1. 1.Abteilung für Experimentelle PathologieMedizinische Hochschule HannoverHannover 61Federal Republic of Germany
  2. 2.Institut für ToxikologieBayer AGWuppertal 1Federal Republic of Germany

Personalised recommendations