, Volume 35, Issue 1, pp 32–38 | Cite as

Loss of regular oscillatory insulin secretion in islet cell antibody positive non-diabetic subjects

  • P. J. Bingley
  • D. R. Matthews
  • A. J. K. Williams
  • G. F. Bottazzo
  • E. A. M. Gale


Basal insulin secretion was compared in nine islet-cell antibody positive, non-diabetic first-degree relatives of children with Type 1 (insulin-dependent) diabetes mellitus and nine normal control subjects matched for age, sex and weight. Acute insulin responses to a 25 g intravenous glucose tolerance test were similar in the two groups (243 (198–229) vs 329 (285–380) mU·l−1·10min−1, mean (±SE), p=0.25). Fasting plasma insulin was assayed in venous samples taken at one min intervals for 2 h. Time series analysis was used to demonstrate oscillatory patterns in plasma insulin. Autocorrelation showed that regular oscillatory activity was generally absent in the islet-cell antibody positive group, whereas a regular 13 min cycle was shown in control subjects (p< 0.0001). Fourier transformation did, however, show a 13 min spectral peak in the islet-cell antibody positive group, consistent with intermittent pulsatility. We conclude that overall oscillatory patters of basal insulin secretion are altered in islet-cell antibody positive subjects even when the acute insulin response is within the normal range.

Key words

Type 1 (insulin-dependent) diabetes mellitus islet-cell antibodies insulin secretion 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. J. Bingley
    • 1
  • D. R. Matthews
    • 2
  • A. J. K. Williams
    • 1
  • G. F. Bottazzo
    • 3
  • E. A. M. Gale
    • 1
  1. 1.Department of Diabetes and MetabolismSt. Bartholomew's HospitalLondonUK
  2. 2.Diabetes Research Laboratories, Nuffield Department of Clinical MedicineRadcliffe InfirmaryOxfordUK
  3. 3.Department of ImmunologyRoyal London HospitalLondonUK

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