Maternally inherited diabetes and deafness: a new diabetes subtype
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Diabetes mellitus is a common disease with many forms of clinical expression. In addition, the development of diabetic complications is not only dependent on glycaemic control but also on individual factors which may be related to genetic heterogeneity. At present, multiple genetic factors are being recognized as contributing to the development of diabetes or possibly modulating its clinical expression. The purpose of this review is to give an overview of our current knowledge on a subtype of diabetes which is apparently caused by a single mutation in the mitochondrial DNA.
KeywordsGenetics maternally inherited diabetes and deafness NIDDM IDDM mitochondria MELAS syndrome
World Health Organization
insulin-dependent diabetes mellitus
non-insulin-dependent diabetes mellitus
maternally inherited diabetes and deafness
maturity onset diabetes of the young
mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
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