Diabetologia

, Volume 39, Issue 4, pp 375–382

Maternally inherited diabetes and deafness: a new diabetes subtype

  • J. A. Maassen
  • T. Kadowaki
Review

Summary

Diabetes mellitus is a common disease with many forms of clinical expression. In addition, the development of diabetic complications is not only dependent on glycaemic control but also on individual factors which may be related to genetic heterogeneity. At present, multiple genetic factors are being recognized as contributing to the development of diabetes or possibly modulating its clinical expression. The purpose of this review is to give an overview of our current knowledge on a subtype of diabetes which is apparently caused by a single mutation in the mitochondrial DNA.

Keywords

Genetics maternally inherited diabetes and deafness NIDDM IDDM mitochondria MELAS syndrome 

Abbreviations

WHO

World Health Organization

IDDM

insulin-dependent diabetes mellitus

NIDDM

non-insulin-dependent diabetes mellitus

mtDNA

mitochondrial DNA

MIDD

maternally inherited diabetes and deafness

MODY

maturity onset diabetes of the young

MELAS

mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. A. Maassen
    • 1
  • T. Kadowaki
    • 2
  1. 1.Department of Medical Biochemistry, Sylvius LaboratoryLeiden UniversityAL LeidenThe Netherlands
  2. 2.Third Department of Internal Medicine, Faculty of MedicineUniversity of TokyoTokyoJapan

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